902667

Propargyl-PEG6-acid

• 别名: 4,7,10,13,16,19-Hexaoxadocos-21-ynoic acid, Propargyl-PEG6-CH2CO2H
• 经验公式（希尔记法）: C₁₆H₂₈O₈
• CAS号: 1951438-84-8
• 分子量: 348.39
• MDL號碼: MFCD28950778
• 分類程式碼代碼: 12352106
• NACRES: NA.22

属性

• 化驗: ≥95%
• 形狀: liquid
• 反應適用性: reaction type: click chemistry; reagent type: cross-linking reagent
• 折射率: n/D 1.469
• 官能基: alkyne; carboxylic acid
• 儲存溫度: −20°C
• SMILES 字串: OC(CCOCCOCCOCCOCCOCCOCC#C)=O
• InChI: 1S/C16H28O8/c1-2-4-19-6-8-21-10-12-23-14-15-24-13-11-22-9-7-20-5-3-16(17)18/h1H,3-15H2,(H,17,18)
• InChI 密鑰: XRSJYQQOJNYUDV-UHFFFAOYSA-N

说明

應用

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophilic PEG linker facilitates solubility in biological applications. Propargyl-PEG6-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

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法律資訊

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

安全信息

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable