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Merck

857459

Sigma-Aldrich

N-乙酰基-L苯丙氨酸

ReagentPlus®, 99%

别名:

(+)-N-Acetylphenylalanine, (S)-2-Acetamido-3-phenylpropanoic acid

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About This Item

线性分子式:
C6H5CH2CH(NHCOCH3)CO2H
CAS号:
分子量:
207.23
EC號碼:
MDL號碼:
分類程式碼代碼:
12352209
eCl@ss:
32160406
PubChem物質ID:
NACRES:
NA.22

品質等級

產品線

ReagentPlus®

化驗

99%

形狀

powder

光學活性

[α]22/D +40.0°, c = 1 in methanol

反應適用性

reaction type: C-H Activation
reaction type: solution phase peptide synthesis
reagent type: ligand
reaction type: Peptide Synthesis

mp

171-173 °C (lit.)

應用

peptide synthesis

官能基

amine
carboxylic acid

SMILES 字串

CC(=O)N[C@@H](Cc1ccccc1)C(O)=O

InChI

1S/C11H13NO3/c1-8(13)12-10(11(14)15)7-9-5-3-2-4-6-9/h2-6,10H,7H2,1H3,(H,12,13)(H,14,15)/t10-/m0/s1

InChI 密鑰

CBQJSKKFNMDLON-JTQLQIEISA-N

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一般說明

N-乙酰基-L-苯基丙氨酸是L-苯基丙氨酸的乙酰基类似物。它被广泛用作反应物,以合成N-乙酰基-L-苯基丙氨酸的甲基或乙基酯,可作为肽合成中的通用构件。

應用

N-乙酰基-L-苯基丙氨酸可用作合成以下物质的反应物:
  • 使用Mukaiyama试剂通过甲醇酯化反应产生N-乙酰苯丙氨酸甲酯。
  • 通过铑催化氢化反应产生乙酰氨基环己烷丙酸。

法律資訊

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Surfactant-protease complex as a novel biocatalyst for peptide synthesis in hydrophilic organic solvents
Okazaki S, et al.
Enzyme and Microbial Technology, 26(2-4), 159-164 (2000)
Corinna Neuber et al.
Analytical chemistry, 86(18), 9065-9073 (2014-08-20)
Sphingosine 1-phosphate (S1P), a bioactive lipid involved in various physiological processes, can be irreversibly degraded by the membrane-bound S1P lyase (S1PL) yielding (2E)-hexadecenal and phosphoethanolamine. It is discussed that (2E)-hexadecenal is further oxidized to (2E)-hexadecenoic acid by the long-chain fatty
K Y Xu
Biochemistry, 28(17), 6894-6899 (1989-08-22)
A combination of competitive labeling with [3H]acetic anhydride [Kaplan, H., Stevenson, K. J., & Hartley, B. S. (1971) Biochem. J. 124, 289-299] and immunoaffinity chromatography is described that permits the assignment of the acid dissociation constant and the absolute nucleophilicity
E Jellum et al.
Scandinavian journal of clinical and laboratory investigation. Supplementum, 184, 21-26 (1986-01-01)
Urinary organic acid profiles of patients with Maple Syrup Urine Disease (MSUD), hereditary tyrosinemia and phenylketonuria (PKU) have been studied by means of capillary GC-MS-computer technique. In addition to the characteristic metabolites of these disorders, increased amounts of N-acetylleucine, N-acetylisoleucine
Edward A Lemke
Methods in molecular biology (Clifton, N.J.), 751, 3-15 (2011-06-16)
Studies of protein structure and function using single-molecule fluorescence resonance energy transfer (smFRET) benefit dramatically from the ability to site-specifically label proteins with small fluorescent dyes. Genetically encoding the unnatural amino acid (UAA) p-acetylphenylalanine is an efficient way to introduce

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