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Merck

852678

Sigma-Aldrich

6-巯基嘌呤 一水合物

98%

别名:

6-嘌呤硫醇, 6-硫代嘌呤

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About This Item

经验公式(希尔记法):
C5H4N4S · H2O
CAS号:
分子量:
170.19
Beilstein:
4012091
EC號碼:
MDL號碼:
分類程式碼代碼:
12352005
PubChem物質ID:
NACRES:
NA.22

品質等級

化驗

98%

形狀

powder

mp

>300 °C (lit.)

SMILES 字串

O.Sc1ncnc2[nH]cnc12

InChI

1S/C5H4N4S.H2O/c10-5-3-4(7-1-6-3)8-2-9-5;/h1-2H,(H2,6,7,8,9,10);1H2

InChI 密鑰

WFFQYWAAEWLHJC-UHFFFAOYSA-N

基因資訊

human ... PPAT(5471)

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一般說明

6-巯基嘌呤一水合物是一种抗代谢物和抗肿瘤药物。它与4-羟基苯甲酸以及2,4-二羟基苯甲酸的共结晶或与哌嗪的盐形成可提高其水溶性。

應用

6-巯基嘌呤是一种广泛使用的抗白血病药物,可通过将硫嘌呤甲基转移酶代谢物插入DNA和RNA而抑制从头的嘌呤合成。

象形圖

Skull and crossbonesHealth hazard

訊號詞

Danger

危險聲明

危險分類

Acute Tox. 3 Oral - Muta. 2 - Repr. 2

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Improving the solubility of 6-Mercaptopurine via cocrystals and salts
Xu LL, et al.
Crystal Growth & Design, 12(12), 6004-6011 (2012)
Unit-cell dimensions and space group of 6-mercaptopurine monohydrate.
Hoogsteen K.
Nature, 178(4529), 379-379 (1956)
Comparative structural and spectrum analyses of 6-mercaptopurine monohydrate and 6-mercaptopurine hydrochloride
Perez-Ruiz E, et al.
Canadian Journal of Analytical Sciences and Spectroscopy, 43(3), 59-67 (1998)
Helmut Gadner et al.
Blood, 121(25), 5006-5014 (2013-04-17)
Langerhans cell histiocytosis (LCH)-III tested risk-adjusted, intensified, longer treatment of multisystem LCH (MS-LCH), for which optimal therapy has been elusive. Stratified by risk organ involvement (high [RO+] or low [RO-] risk groups), > 400 patients were randomized. RO+ patients received
Clinical pharmacogenetics implementation consortium guidelines for thiopurine methyltransferase genotype and thiopurine dosing: 2013 update.
M V Relling et al.
Clinical pharmacology and therapeutics, 93(4), 324-325 (2013-02-21)

商品

Neoplastic cells are highly dependent on the de novo synthesis of nucleotides to maintain sufficient pools to support DNA replication and the production of RNA.

Global Trade Item Number

货号GTIN
852678-1G-A4061833023976
852678-25G-A
852678-5G-A4061833023990

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