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Merck

778966

Sigma-Aldrich

(2-羟丙基)-β-环糊精

produced by Wacker Chemie AG, Burghausen, Germany

别名:

Cavasol® W7 HP, HP-β-CD

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About This Item

EC號碼:
分類程式碼代碼:
12352201
NACRES:
NA.22

等級

produced by Wacker Chemie AG, Burghausen, Germany

形狀

powder

標籤範圍

molar substitution per 0.60

雜質

≤1.0% unsubstituted cyclodextrin
≤5.0% polypropylene glycol

燃燒殘留物

≤2.5%

損耗

≤7.0% loss on drying

SMILES 字串

CC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O

InChI

1S/C63H112O42/c1-22(64)8-85-15-29-50-36(71)43(78)57(92-29)100-51-30(16-86-9-23(2)65)94-59(45(80)38(51)73)102-53-32(18-88-11-25(4)67)96-61(47(82)40(53)75)104-55-34(20-90-13-27(6)69)98-63(49(84)42(55)77)105-56-35(21-91-14-28(7)70)97-62(48(83)41(56)76)103-54-33(19-89-12-26(5)68)95-60(46(81)39(54)74)101-52-31(17-87-10-24(3)66)93-58(99-50)44(79)37(52)72/h22-84H,8-21H2,1-7H3/t22?,23?,24?,25?,26?,27?,28?,29-,30-,31?,32?,33?,34?,35?,36?,37-,38?,39-,40+,41+,42+,43?,44+,45?,46+,47+,48+,49+,50+,51+,52-,53-,54-,55-,56-,57+,58-,59+,60-,61-,62-,63-/m1/s1

InChI 密鑰

ODLHGICHYURWBS-RYJYQAAZSA-N

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一般說明

(2-羟丙基)- β -环糊精(HP-β-CD)是一种大环寡糖,由疏水性内部空腔和亲水性外表面组成,空腔可容纳疏水性药物,用于增强难溶药物的水溶性和生物利用度。它还具有高表面活性和稳定性。

應用

2-羟丙基)-β-环糊精可用作:
  • 单相四方锆氧化物合成中的大分子添加剂。
  • 聚轮烷合成前体。
  • 药物制剂中的增溶剂和稳定剂。HP-β-CD也具有潜在的抗癌活性。
亲脂性药物的溶解度随着水溶液中的羟丙基-β-环糊精(HBC)浓度线性增加,这是因为HBC与药物形成了复合物。这种客体-宿主型复合物在药物与HBC的非极性空穴间形成,导致溶解度增强。 可以将溶液冻干以产生易溶的粉末。 对家兔和小鼠无毒性。

法律資訊

Cavasol is a registered trademark of Wacker Chemie AG

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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访问文档库

?Back to the future?: a new look at hydroxypropyl beta-cyclodextrins.
Malanga M, et al.
Journal of Pharmaceutical Sciences, 105(9), 2921-2931 (2016)
2-Hydroxypropyl-?-cyclodextrin acts as a novel anticancer agent.
Yokoo M, et al.
PLoS ONE, 10(11), e0141946-e0141946 (2015)
2-Hydroxypropyl-?-cyclodextrin (HP-?-CD): a toxicology review.
Gould S & Scott RC.
Food And Chemical Toxicology, 43(10), 1451-1459 (2005)
Weijin Wang et al.
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