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Merck

77386

Sigma-Aldrich

2-溴-1-乙基吡啶四氟硼酸盐

≥97.0% (T)

别名:

BEP

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About This Item

经验公式(希尔记法):
C7H9BBrF4N
CAS号:
分子量:
273.86
Beilstein:
4059265
EC號碼:
MDL號碼:
分類程式碼代碼:
12352005
PubChem物質ID:
NACRES:
NA.22

品質等級

化驗

≥97.0% (T)

形狀

crystals

反應適用性

reaction type: Coupling Reactions

mp

103-107 °C

應用

peptide synthesis

官能基

bromo

SMILES 字串

F[B-](F)(F)F.CC[n+]1ccccc1Br

InChI

1S/C7H9BrN.BF4/c1-2-9-6-4-3-5-7(9)8;2-1(3,4)5/h3-6H,2H2,1H3;/q+1;-1

InChI 密鑰

YJDXVQLBIAJTHP-UHFFFAOYSA-N

一般說明

2-Bromo-1-ethyl-pyridinium tetrafluoroborate is a coupling reagent employed in the synthesis of amides and esters through amidation and esterification reactions, respectively. It is generally prepared by the reaction of triethyloxonium tetrafluoroborate with 2?bromo pyridine.

應用

2-Bromo-1-ethyl-pyridinium tetrafluoroborate can be used as a coupling reagent for:
  • The synthesis of N-methylated peptides in solution and solid phase.
  • The synthesis of cyclosporin A fragment and dolastatin 15 pentapeptide moiety.

其他說明

用于肽合成的偶联试剂;与其他试剂如 BOP、PyBrOP、PyClU、BTFFH、CMBI 相比,外消旋作用更低、反应更快

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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