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品質等級
化驗
97%
形狀
solid
反應適用性
reagent type: ligand
mp
197-212 °C
SMILES 字串
COc1ccnc2c1ccc3c(OC)ccnc23
InChI
1S/C14H12N2O2/c1-17-11-5-7-15-13-9(11)3-4-10-12(18-2)6-8-16-14(10)13/h3-8H,1-2H3
InChI 密鑰
ZPGVCQYKXIQWTP-UHFFFAOYSA-N
一般說明
4,7-二甲氧基-1,10-菲咯啉是一种有机化合物,可用作化学合成中的高效配体。在铜催化剂存在的情况下,它与芳基碘和芳基溴进行咪唑的N-芳基化。使用该催化剂可以进行各种受阻和功能化咪唑和芳基卤的转化反应。
應用
用于 Cu-催化的咪唑 N-芳基化的配体
訊號詞
Danger
危險聲明
危險分類
Acute Tox. 4 Oral - Aquatic Acute 1 - Eye Dam. 1
儲存類別代碼
11 - Combustible Solids
水污染物質分類(WGK)
WGK 3
閃點(°F)
Not applicable
閃點(°C)
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
Organic letters, 9(4), 643-646 (2007-02-09)
With use of Cu-based catalysts, 2- and 4-hydroxypyridines were N-arylated in modest to excellent yields. In the case of 2-hydroxypyridine, the use of 4,7-dimethoxy-1,10-phenanthroline, 3, expanded the scope of previous literature reports to include the use of N-containing heteroaryl halides
Tetrahedron Letters, 45, 4257-4257 (2004)
Journal of the American Chemical Society, 124(25), 7421-7428 (2002-06-20)
An experimentally simple and inexpensive catalyst system was developed for the amidation of aryl halides by using 0.2-10 mol % of CuI, 5-20 mol % of a 1,2-diamine ligand, and K(3)PO(4), K(2)CO(3), or Cs(2)CO(3) as base. Catalyst systems based on
Organic letters, 8(13), 2779-2782 (2006-06-16)
[reaction: see text] 4,7-Dimethoxy-1,10-phenanthroline (L) was found to be an efficient ligand for the copper-catalyzed N-arylation of imidazole with aryl iodides and bromides under mild conditions. A variety of hindered and functionalized imidazoles and aryl halides were transformed in good
The Journal of organic chemistry, 72(16), 6190-6199 (2007-07-13)
4,7-Dimethoxy-1,10-phenanthroline (L1c) was found to be an efficient ligand for the copper-catalyzed N-arylation of imidazoles and benzimidazoles with both aryl iodides and bromides under mild conditions. Further optimization of the system has revealed that the addition of poly(ethylene glycol) accelerates
商品
Buchwald phosphine ligands for C-C, C-N, and C-O bond formation.
Buchwald phosphine ligands for C-C, C-N, and C-O bond formation.
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