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466964

Sigma-Aldrich

4'-氟-2'-羟基苯乙酮

98%

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About This Item

线性分子式:
FC6H3(OH)COCH3
CAS号:
1481-27-2
分子量:
154.14
MDL號碼:
MFCD00143203
分類程式碼代碼:
12352100
PubChem物質ID:
24870373
NACRES:
NA.22

品質等級

100

化驗

98%

mp

31-35 °C (lit.)

官能基

fluoro
ketone

SMILES 字串

CC(=O)c1ccc(F)cc1O

InChI

1S/C8H7FO2/c1-5(10)7-3-2-6(9)4-8(7)11/h2-4,11H,1H3

InChI 密鑰

HLTBTUXAMVOKIH-UHFFFAOYSA-N

相关类别

一般說明

4′-Fluoro-2′-hydroxyacetophenone is a substituted acetophenone derivative. Biological Baeyer-Villiger oxidation of 4′-fluoro-2′-hydroxyacetophenone to 4-fluorocatechol by using whole cells of Pseudomonas fluorescens ACB has been reported. Its crystals belong to the monoclinic crystal system and space group P21/n.

應用

最近用于制备具有药用活性的苯并[b]呋喃类化合物和噻吩类化合物。
4′-Fluoro-2′-hydroxyacetophenone may be used in the preparation of series of 4′-fluoro-2′-hydroxychalcones, via aldol condensation with substituted aldehydes followed by cyclization with hydrazine hydrate.

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H315,H319,H335

危險分類

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類（WGK）

WGK 3

閃點（°F）

210.2 °F - closed cup

閃點（°C）

99 °C - closed cup

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves

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分析证书(COA)

Lot/Batch Number
MKCQ2223
MKCH0574
MKCF7194
MKCC2528
MKBW4712V

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4'-Fluoro-2'-hydroxyacetophenone.
Rizal MR and Ng SW.
Acta Crystallographica Section E, Structure Reports Online, 64(5), o916-o916 (2008)
Khaled R A Abdellatif et al.
Journal of enzyme inhibition and medicinal chemistry, 30(3), 484-491 (2014-09-10)
In an effort to develop safe and potent anti-inflammatory agents, a series of novel 4'-fluoro-2'-hydroxychalcones 5a-d and their dihydropyrazole derivatives 6a-d was prepared. It was synthesized via aldol condensation of 4'-fluoro-2'-hydroxyacetophenone with appropriately substituted aldehydes followed by cyclization with hydrazine
M J Moonen et al.
Journal of industrial microbiology & biotechnology, 26(1-2), 35-42 (2001-09-11)
The biological Baeyer-Villiger oxidation of acetophenones was studied by 19F nuclear magnetic resonance (NMR). The 19F NMR method was used to characterise the time-dependent conversion of various fluorinated acetophenones in either whole cells of Pseudomonas fluorescens ACB or in incubations
Journal of Heterocyclic Chemistry, 30, 445-445 (1993)

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