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化驗
97%
形狀
powder
mp
139-142 °C (dec.) (lit.)
SMILES 字串
O=C1C=Cc2ccccc2C1=O
InChI
1S/C10H6O2/c11-9-6-5-7-3-1-2-4-8(7)10(9)12/h1-6H
InChI 密鑰
KETQAJRQOHHATG-UHFFFAOYSA-N
基因資訊
human ... PTPRC(5788)
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一般說明
1,2-萘醌是萘的主要代谢产物之一，它负责发挥其相关的细胞毒性和遗传毒性。 1,2-萘醌是一种大气污染物。它通过激活表皮生长因子受体，引起豚鼠气管平滑肌的收缩。 据报道，1,2-萘醌是柴油废气颗粒（DEP）和大气颗粒物中的环境醌。
應用
在利用扫描电化学显微镜（SECM）对正常人乳房（MCF-10A）细胞的氧化还原活性进行电化学作图时，1,2-萘醌被用作介质。
訊號詞
Warning
危險分類
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
標靶器官
Respiratory system
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
B Liu et al.
Proceedings of the National Academy of Sciences of the United States of America, 97(18), 9855-9860 (2000-08-30)
Electrochemical methods have been widely used to monitor physiologically important molecules in biological systems. This report describes the first application of the scanning electrochemical microscope (SECM) to probe the redox activity of individual living cells. The possibilities of measuring the
Shota Kikuno et al.
Toxicology and applied pharmacology, 210(1-2), 47-54 (2005-07-26)
1,2-Naphthoquinone (1,2-NQ) has recently been identified as an environmental quinone in diesel exhaust particles (DEP) and atmospheric PM2.5. We have found that this quinone is capable of causing a concentration-dependent contraction of tracheal smooth muscle in guinea pigs with EC50
Soraia K P Costa et al.
Archives of toxicology, 84(2), 109-117 (2009-04-29)
The environmental chemical 1,2-naphthoquinone (1,2-NQ) is implicated in the exacerbation of airways diseases induced by exposure to diesel exhaust particles (DEP), which involves a neurogenic-mediated mechanism. Plasma extravasation in trachea, main bronchus and lung was measured as the local (125)I-bovine
Wan-Yun Cheng et al.
Environmental health perspectives, 120(2), 267-274 (2011-10-15)
Toxicological studies have correlated inflammatory effects of diesel exhaust particles (DEP) with its organic constituents, such as the organic electrophile 1,2-naphthoquinone (1,2-NQ). To elucidate the mechanisms involved in 1,2-NQ-induced inflammatory responses, we examined the role of oxidant stress in 1,2-NQ-induced
Takashi Miura et al.
Chemical research in toxicology, 24(11), 1836-1844 (2011-08-11)
Many cellular proteins with reactive thiols form covalent bonds with electrophiles, thereby modifying their structures and activities. Here, we describe the recovery of a glycolytic protein, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), from such an electrophilic attack by 1,2-napthoquinone (1,2-NQ). GAPDH readily formed
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