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品質等級
化驗
98%
形狀
powder or crystals
mp
143-146 °C (lit.)
溶解度
water: soluble 100 mg/mL, clear to very slightly hazy, colorless
官能基
carboxylic acid
SMILES 字串
OC(=O)CP(O)(O)=O
InChI
1S/C2H5O5P/c3-2(4)1-8(5,6)7/h1H2,(H,3,4)(H2,5,6,7)
InChI 密鑰
XUYJLQHKOGNDPB-UHFFFAOYSA-N
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一般說明
膦酰基乙酸可在病毒感染的人成纤维细胞中抑制特异性的人巨细胞病毒DNA合成。它还能够抑制感染细胞中单纯疱疹病毒DNA的合成以及在体外病毒特异性DNA聚合酶的活性。
應用
膦酰基乙酸已被用作病毒DNA复制的一种抑制剂，以研究受感染的低传代牛细胞中感染细胞蛋白0（bICP0）的定位。它还可以磷酸盐非依赖性方式用作微生物生长的一种磷源。
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
Not applicable
閃點（°C）
Not applicable
個人防護裝備
dust mask type N95 (US), Eyeshields, Gloves
其他客户在看
R W Honess et al.
Journal of virology, 21(2), 584-600 (1977-02-01)
Phosphonoacetic acid (PAA) inhibited the synthesis of herpes simplex virus DNA in infected cells and the activity of the virus-specific DNA polymerase in vitro. In the presence of concentrations of PAA sufficient to prevent virus growth and virus DNA synthesis
Alireza Mahmoudian et al.
Comparative immunology, microbiology and infectious diseases, 35(2), 103-115 (2011-12-27)
The kinetics of expression of only a few genes of infectious laryngotracheitis virus (ILTV) have been determined, using northern blot analysis. We used quantitative reverse transcriptase PCR to examine the kinetics of expression of 74 ILTV genes in LMH cells.
E S Huang
Journal of virology, 16(6), 1560-1565 (1975-12-01)
Phosphonoacetic acid specifically inhibited human cytomegalovirus DNA synthesis in virus-infected human fibroblasts as detected by virus-specific nucleic acid hybridization. Inhibition was reversible; viral DNA synthesis resumed upon the removal of the drug. The compound partially inhibited DNA synthesis of host
Jacqueline P Smits et al.
The Journal of organic chemistry, 76(21), 8807-8813 (2011-09-16)
The α-trisphosphonic acid esters provide a unique spatial arrangement of three phosphonate groups and may represent an attractive motif for inhibitors of enzymes that utilize di- or triphosphate substrates. To advance studies of this unique functionality, a general route to
Magdalena Klimek-Ochab
Folia microbiologica, 59(5), 375-380 (2014-02-27)
A psychrophilic fungal strain of Geomyces pannorum P15 was screened for its ability to utilize a range of synthetic and natural organophosphonate compounds as the sole source of phosphorus, nitrogen, or carbon. Only phosphonoacetic acid served as a phosphorus source
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