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Merck

143057

Sigma-Aldrich

Aldrithiol-4

98%

别名:

4,4'-二吡啶基二硫醚, 4,4'-二硫二吡啶

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About This Item

经验公式(希尔记法):
C10H8N2S2
CAS号:
分子量:
220.31
EC號碼:
MDL號碼:
分類程式碼代碼:
12352100
PubChem物質ID:
NACRES:
NA.22

化驗

98%

形狀

solid

mp

76-78 °C (lit.)

溶解度

95% ethanol: soluble 5%, clear, colorless to light yellow

官能基

disulfide

儲存溫度

2-8°C

SMILES 字串

S(Sc1ccncc1)c2ccncc2

InChI

1S/C10H8N2S2/c1-5-11-6-2-9(1)13-14-10-3-7-12-8-4-10/h1-8H

InChI 密鑰

UHBAPGWWRFVTFS-UHFFFAOYSA-N

應用

  • Aldrithiol -4 在一项研究中被用作共底物,通过 体外进化技术 :噬菌体展示 开发出针对甘露糖结合凝集素相关丝氨酸蛋白酶的高度特异性抑制剂。
  • 用于研究在接近生理条件下测定的重组人脑红蛋白和细胞红蛋白的 O2 平衡
  • 用于修饰蛋白研究的金表面

法律資訊

Aldrithiol is a trademark of Sigma-Aldrich Co. LLC

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Nikitas Bistolas et al.
Biochemical and biophysical research communications, 314(3), 810-816 (2004-01-27)
The spectroelectrochemistry of camphor-bound cytochrome P450cam (P450cam) using gold electrodes is described. The electrodes were modified with either 4,4(')-dithiodipyridin or sodium dithionite. Electrolysis of P450cam was carried out when the enzyme was in solution, while at the same time UV-visible
Shwu-Jiuan Sheu et al.
Investigative ophthalmology & visual science, 44(3), 1237-1244 (2003-02-26)
To identify the mechanisms by which oxidative stress with oxidizing agents alters the activity of ion channels in human retinal pigment epithelial (RPE) cells. The effects of oxidizing agents on ion currents were investigated in human RPE R-50 cells with
J. Vac. Sci. Technol. B, 12, 1486-1486 (1994)
Rosa E Hansen et al.
Analytical biochemistry, 363(1), 77-82 (2007-02-09)
Experimental determination of the number of thiols in a protein requires methodology that combines high sensitivity and reproducibility with low intrinsic thiol oxidation disposition. In detection of disulfide bonds, it is also necessary to efficiently reduce disulfides and to quantify
H Reynaldo López-Mirabal et al.
FEMS yeast research, 7(3), 391-403 (2007-01-27)
Dipyridyl disulfide (DPS) is a highly reactive thiol oxidant that functions as electron acceptor in thiol-disulfide exchange reactions. DPS is very toxic to yeasts, impairing growth at low micromolar concentrations. The genes TRX2 (thioredoxin), SOD1 (superoxide dismutase), GSH1 (gamma-glutamyl-cysteine synthetase)

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