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F6892

Sigma-Aldrich

法尼焦磷酸 铵盐

methanol:ammonia solution, ≥95% (TLC)

别名:

3,7,11-三甲基-2,6,10-十二碳三烯-1-基焦磷酸 铵盐, FPP

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About This Item

经验公式（希尔记法）:
C15H37N3O7P2
CAS号:
13058-04-3
分子量:
433.42
MDL號碼:
MFCD00189688
分類程式碼代碼:
12352204
PubChem物質ID:
24894923
NACRES:
NA.83

品質等級

100

化驗

≥95% (TLC)

形狀

methanol:ammonia solution

包裝

vial of 200 μg

儲存溫度

−20°C

SMILES 字串

C\C(C)=C\CC\C(C)=C\CC\C(C)=C\COP(O)(=O)OP(O)(O)=O

InChI

1S/C15H28O7P2/c1-13(2)7-5-8-14(3)9-6-10-15(4)11-12-21-24(19,20)22-23(16,17)18/h7,9,11H,5-6,8,10,12H2,1-4H3,(H,19,20)(H2,16,17,18)/b14-9+,15-11+

InChI 密鑰

VWFJDQUYCIWHTN-YFVJMOTDSA-N

基因資訊

rat ... Fnta(25318)

相关类别

一般說明

法尼基焦磷酸是由15碳组成的类异戊二烯，在法尼基焦磷酸合成酶（FPPS）的作用下由牻牛儿焦磷酸（GPP）合成。

應用

法尼基焦磷酸铵盐用于：
  • 用作人成骨肉瘤细胞的异戊二烯化激动剂，用于基于胶原的细胞侵袭试验
  • 人脐静脉内皮细胞（HUVECs）中肝细胞生长因子（HGF）的异戊二烯化
  • 用作底物，用于硅藻（Haslea ostrearia） 异戊二烯基转移酶测定。

生化／生理作用

法尼基焦磷酸（FPP）是生物合成胆固醇、泛醌和多萜醇的前体。是细胞内甲羟戊酸途径的一部分。FPP是细胞存活所必需的物质，用于某些低分子质量G蛋白（含Ras）的异戊二烯化。抑制异戊二烯化可造成Ras蛋白丧失致癌潜能。抑制异戊二烯化具有治疗潜力，或可用于突触可塑性和阿尔兹海默′病的治疗。

外觀

甲醇溶液：10mM水溶性NH4OH (7:3)
实际浓度见标签

訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 1

儲存類別代碼

3 - Flammable liquids

水污染物質分類（WGK）

WGK 2

閃點（°F）

60.8 °F

閃點（°C）

16 °C

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
MKCP0257
MKCK0366
MKCK0723
MKCG0521
MKCD7518

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