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化驗
99%
形狀
solid
bp
243 °C (lit.)
mp
46-48 °C (lit.)
溶解度
H2O: freely soluble
organic solvents: soluble
SMILES 字串
c1ccc2ncncc2c1
InChI
1S/C8H6N2/c1-2-4-8-7(3-1)5-9-6-10-8/h1-6H
InChI 密鑰
JWVCLYRUEFBMGU-UHFFFAOYSA-N
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一般說明
Quinazolines has applications in medicinal chemistry due to their antibacterial, antifungal, anticonvulsant, anti-inflammatory and antitumor activities. It is the basic structural unit of pharmaceuticals and plays an important role in modern synthesis of antitumor drugs.
應用
Quinazoline was used to study the electrochemical behaviour of quinazoline using modern polarographic and voltammetric methods.
生化／生理作用
Genotoxicity of quinazoline was established by bacterial SOS Chromotest (Escherichia Coli).
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
閃點（°F）
222.8 °F - closed cup
閃點（°C）
106 °C - closed cup
個人防護裝備
Eyeshields, Gloves, type N95 (US)
Zhijiang Fan et al.
Molecular diversity, 22(3), 657-667 (2018-03-27)
A series of structurally novel 3-thioether-1-(quinazolin-4-yl)-1H-1,2,4-triazol-5-amine derivatives (7a-7r) were designed and synthesized based on a pharmacophore hybrid approach, and screened for their antibacterial and antifungal activities in vitro. All the target compounds were fully characterized through [Formula: see text]H NMR
Elham Bagheri et al.
Current pharmaceutical design, 24(13), 1395-1404 (2018-02-01)
Quinazoline is an aromatic bicyclic compound exhibiting several pharmaceutical and biological activities. This study was conducted to investigate the potential wound healing properties of Synthetic Quinazoline Compound (SQC) on experimental rats. The toxicity of SQC was determined by MTT cell
Siva Jyothi Buggana et al.
Computational biology and chemistry, 79, 110-118 (2019-02-21)
Recent studies reported the involvement of JAK2/STAT3 pathway in various solid tumours including breast, ovarian, prostate and lung cancers. Clinical literature also reported the lowered burden in breast and ovarian cancers by targeting JAK2 pathway. In this study, a series
Polarographic and voltammetric determination of quinazoline-the structural unit of anticancer drugs.
Hladikova J, et al.
Sensing in Electroanalysis, 3, 165-175 (2008)
Reddy Amala et al.
BioImpacts : BI, 11(1), 15-22 (2021-01-21)
Introduction: Inflammation is the primary response caused due to harmful stimuli which are followed by the increased draining of plasma and immune cells from the body into the site of the injured tissue. A signaling cascade of growth factors and
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