103276

哈尔满碱

98%

• 别名: 1-甲基-9H-吡啶并[3,4-b]吲哚, 2-甲基-β-咔啉, 阿锐碱
• 经验公式（希尔记法）: C₁₂H₁₀N₂
• CAS号: 486-84-0
• 分子量: 182.22
• Beilstein: 143898
• EC號碼: 207-642-2
• MDL號碼: MFCD00004957
• 分類程式碼代碼: 12352100
• PubChem物質ID: 24846602
• NACRES: NA.22

属性

• 品質等級: 100
• 化驗: 98%
• drug control: stupéfiant (France)
• mp: 235-238 °C (lit.)
• 溶解度: methanol: soluble 50mg/ml
• SMILES 字串: Cc1nccc2c3ccccc3[nH]c12
• InChI: 1S/C12H10N2/c1-8-12-10(6-7-13-8)9-4-2-3-5-11(9)14-12/h2-7,14H,1H3
• InChI 密鑰: PSFDQSOCUJVVGF-UHFFFAOYSA-N
• 基因資訊: human ... CYP2D6(1565) ; rat ... Gabra2(29706)

说明

一般說明

• Harmane is a potent tremor-producing β-carboline alkaloid and neurotoxin.
• It is major representative of heterocyclic aromatic amines, a group of mutagenic and carcinogenic substances which are formed in meat from the precursors creatine, creatinine, amino acids and sugars during the heating at high temperatures.
• Blood harmane concentration is elevated in essential tremor, late-life neurological disease.

應用

• Harmane was used in trace level determination of harmane by planar chromatography coupled with (tandem) mass spectrometry.
• It was used to study interactions of norharman and harman with DNA.
• It may be used as matrix for analysis of cyclodextrins and for sulfated oligosaccharides in combination with DHB as co-matrix.

生化／生理作用

I₁ 咪唑啉结合位点激动剂。

準備報告

Harmane dissolves in methanol at a concentration of 50mg/ml to form a clear, colourless to yellow solution.

安全信息

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H302,H315
• 防範說明: P264 - P280 - P301 + P312 - P302 + P352 - P332 + P313 - P362 + P364
• 危險分類: Acute Tox. 4 Oral - Skin Irrit. 2
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)