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Merck

CHRM1

cholinergic receptor, muscarinic 1

别名:
HM1, M1, M1R
物种:
Human CHRM1 (1128), Mouse Chrm1 (12669), Rat Chrm1 (25229), cow CHRM1 (281684), Horse CHRM1 (100064117), domestic cat CHRM1 (101093801), domestic cat CHRM1 (493664), dog CHRM1 (483776), naked mole-rat Chrm1 (101702102), domestic guinea pig Chrm1 (100728041)
UniProtKB ID:
P11229
基因ID:
  • Human(1128) Summary: The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13. [provided by RefSeq, Jul 2008]
  • Mouse(12669) cholinergic receptor, muscarinic 1, CNS
  • Rat(25229) cholinergic receptor, muscarinic 1
  • cow(281684) cholinergic receptor, muscarinic 1
  • Horse(100064117) cholinergic receptor, muscarinic 1
  • domestic cat(101093801) cholinergic receptor, muscarinic 1
  • domestic cat(493664) cholinergic receptor, muscarinic 1
  • dog(483776) cholinergic receptor, muscarinic 1
  • naked mole-rat(101702102) cholinergic receptor, muscarinic 1
  • domestic guinea pig(100728041) cholinergic receptor, muscarinic 1
  • sheep(101117029) cholinergic receptor, muscarinic 1

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Small Molecule - Agonist

Product Number
说明
物种
PHR1493
盐酸毛果芸香碱, Pharmaceutical Secondary Standard; Certified Reference Material,
物种
human
1538902
毛果芸香碱 盐酸盐, United States Pharmacopeia (USP) Reference Standard,
物种
human
1539009
硝酸毛果芸香碱, United States Pharmacopeia (USP) Reference Standard,
物种
human
PHL80370
毛果芸香碱 盐酸盐, phyproof® Reference Substance,
物种
human
P1650000
毛果芸香碱 盐酸盐, European Pharmacopoeia (EP) Reference Standard,
物种
human

Small Molecule - Antagonist

Product Number
说明
物种
197602
奎宁环, 97%,
物种
rat
E5406
爱普杷嗪 盐酸盐, ≥98% (HPLC), powder,
物种
human
PHR1470
东莨菪碱氢溴酸盐, Pharmaceutical Secondary Standard; Certified Reference Material,
物种
human
SML0847
苯扎托品 甲磺酸盐, ≥98% (HPLC),
物种
human
P7412
哌仑西平 二盐酸盐, ≥98% (TLC), powder,
物种
human

Antibodies

Product Number
说明
物种反应性
应用
AB5164
Anti-Muscarinic Acetylcholine Receptor m1 Antibody, Chemicon®, from rabbit,
物种反应性
mouse, rat
应用
immunohistochemistry
western blot
HPA014101
Anti-CHRM1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
SAB4500244
Anti-CHRM1 antibody produced in rabbit, affinity isolated antibody,
物种反应性
human, mouse, rat
应用
ELISA
western blot
M9808
抗 毒蕈碱乙酰胆碱受体 (M 1 ) 兔抗, affinity isolated antibody, lyophilized powder,
物种反应性
mouse, rat
应用
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
说明
物种
P127
(+)-Pentazocine, solid,
物种
rat, human
A8404
盐酸阿米替林 盐酸盐, ≥98% (TLC), powder,
物种
human
C8912
可卡因 游离碱, ,
物种
mouse, rat, human
D4526
多塞平 盐酸盐, ~85% E-isomer basis, ≥98% (GC), 15% Z-isomer basis, powder,
物种
human
H1512
氟哌啶醇, powder,
物种
human, rat

Small Molecule - Ligand

Product Number
说明
物种
A138
Aminobenztropine, solid,
物种
human
C8912
可卡因 游离碱, ,
物种
mouse, rat, human

Proteins

Product Number
说明
物种
HTS044M
ChemiScreen Membrane Preparation Human Recombinant M1 Muscarinic Acetylcholine Receptor, Human M1 GPCR membrane prepation for Radioligand binding Assays.,
物种
human
HTS044RTA
Ready-to-Assay M1 Acetylcholine (Muscarinic) Family Receptor Frozen Cells, ,
物种
human

esiRNA

Product Number
说明
物种
EHU009821
MISSION® esiRNA, targeting human CHRM1,
物种
human