PZ0187

Begacestat

≥98% (HPLC)

• Synonym(s): 5-Chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2- (trifluoromethyl)propyl] thiophene-2-sulfonamide, GSI-953
• Empirical Formula (Hill Notation): C₉H₈ClF₆NO₃S₂
• CAS Number: 769169-27-9
• Molecular Weight: 391.74
• MDL number: MFCD18782675
• UNSPSC Code: 51111800
• PubChem Substance ID: 329823761
• NACRES: NA.77

Properties

• Quality Level: 100
• Assay: ≥98% (HPLC)
• form: powder
• color: white to tan
• solubility: DMSO: ≥15 mg/mL
• storage temp.: 2-8°C
• SMILES string: OC[C@@H](NS(=O)(=O)c1ccc(Cl)s1)C(C(F)(F)F)C(F)(F)F
• InChI: 1S/C9H8ClF6NO3S2/c10-5-1-2-6(21-5)22(19,20)17-4(3-18)7(8(11,12)13)9(14,15)16/h1-2,4,7,17-18H,3H2/t4-/m1/s1
• InChI key: PSXOKXJMVRSARX-SCSAIBSYSA-N
• Gene Information: human ... APH1A(51107) , APH1B(83464) , NCSTN(23385) , PSEN1(5663) , PSEN2(5664) , PSENEN(55851)

Description

Biochem/physiol Actions

Begacestat (GSI-953) is a selective γ-secretase inhibitor that selectively inhibits cleavage of APP over Notch.

Begacestat is a potent APP-selective γ-secretase inhibitor (GSI) that is well-tolerated in mouse and dog.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable