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S0278

Sigma-Aldrich

(±)-Sotalol hydrochloride

≥98% (TLC), powder, β-Adrenoceptor antagonist

Synonyme(s) :

N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide hydrochloride

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About This Item

Formule empirique (notation de Hill):
C12H20N2O3S · HCl
Numéro CAS:
959-24-0
Poids moléculaire :
308.82
Numéro CE :
213-496-0
Numéro MDL:
MFCD00242937
Code UNSPSC :
12352200
ID de substance PubChem :
24278689
Nomenclature NACRES :
NA.77

Nom du produit

(±)-Sotalol hydrochloride, ≥98% (TLC), powder

Niveau de qualité

200

Essai

≥98% (TLC)

Forme

powder

Couleur

white to off-white

Solubilité

H2O: 20 mg/mL

Auteur

Bayer

Chaîne SMILES 

Cl.CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1

InChI

1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H

Clé InChI

VIDRYROWYFWGSY-UHFFFAOYSA-N

Informations sur le gène

human ... ADRB1(153) , ADRB2(154) , ADRB3(155) , KCNH2(3757)

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Application

(±)-Sotalol hydrochloride has been used to test its effect on the cardiac action potential (AP) in human hearts. It has also been used as an β- blocker to determine its effect on free intracellular calcium (Ca2+) release and whole-cell currents in mammalian cancer cells.

Actions biochimiques/physiologiques

Potent β-adrenoceptor antagonist; class III antiarrhythmic; prolongs the action potential and increases the refractory period.
Sotalol has a potential to block non-cardioselective β-adrenergic receptors. It acts as an anti-arrhythmic agent and is used as a therapeutic for equine arrhythmias. In addition, sotalol also has an ability to stop atrial fibrillation recurrence.

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

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Certificats d'analyse (COA)

Lot/Batch Number
026M4004V
019M4094V
119M4022V
127M4132V
047M4111V

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

László Drimba et al.
Journal of cardiovascular pharmacology, 60(2), 208-218 (2012-05-25)
High-fat diet and consequent metabolic syndrome (MS) can lead to elevated risk for cardiac arrhythmias. This preclinical study was to investigate if cicletanine (CIC) could produce cardioprotective effects in conscious rabbits exhibiting the main symptoms of MS. NZW rabbits that
[QTc-prolongation in acute drug-poisoning. Guidelines for management from the Swedish Poisons Information Centre].
Jonas Höjer
Lakartidningen, 110(19-20), 953-955 (2013-06-12)
Kyle A Arsenault et al.
The Cochrane database of systematic reviews, 1(1), CD003611-CD003611 (2013-02-27)
Atrial fibrillation is a common post-operative complication of cardiac surgery and is associated with an increased risk of post-operative stroke, increased length of intensive care unit and hospital stays, healthcare costs and mortality. Numerous trials have evaluated various pharmacological and
Alexander Burashnikov et al.
Circulation. Arrhythmia and electrophysiology, 5(2), 400-408 (2012-02-11)
Several clinical trials have shown that vernakalant is effective in terminating recent onset atrial fibrillation (AF). The electrophysiological actions of vernakalant are not fully understood. Here we report the results of a blinded study comparing the in vitro canine atrial
A Antony Muthu Prabhu et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 96, 95-107 (2012-06-05)
The inclusion complexation behavior of salbutamol, sotalol and atenolol drugs with β-cyclodextrin (β-CD) were investigated by UV-visible, fluorometry, time resolved fluorescence, FT-IR, (1)H NMR, SEM and PM3 methods. The above drugs gave a single emission maximum in water where as
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