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M1275

Sigma-Aldrich

Naproxen sodium

98.0-102.0%

Synonyme(s) :

(S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid sodium salt

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About This Item

Formule empirique (notation de Hill):
C14H13NaO3
Numéro CAS:
26159-34-2
Poids moléculaire :
252.24
Numéro CE :
247-486-2
Numéro MDL:
MFCD00058507
Code UNSPSC :
12352200
ID de substance PubChem :
57654352
Nomenclature NACRES :
NA.77

Source biologique

synthetic (organic)

Niveau de qualité

200

Pureté

98.0-102.0%

Forme

powder

Solubilité

water: 100 mg/mL, clear to slightly hazy, colorless to faintly yellow

Auteur

Bayer

Chaîne SMILES 

[Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O

InChI

1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1

Clé InChI

CDBRNDSHEYLDJV-FVGYRXGTSA-M

Informations sur le gène

human ... PTGS1(5742) , PTGS2(5743)

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Description générale

Naproxen belongs to phenylacetic acid class of Non-steroidal anti-inflammatory drugs (NSAIDs).

Application

Naproxen sodium has been used to evaluate the thermodynamics of biomolecular interaction with bovine and human serum albumin. It has also been used to evaluate its efficiency in reducing the response of spinal dorsal horn neurons to noxious knee joint rotation.

Actions biochimiques/physiologiques

Naproxen binds preferably to serum albumin. The S-enantiomer of naproxen is 28-fold more potential as an anti-inflammatory drug compared to the R-isomer. The R-isomer is found to be a liver toxin and causes gastrointestinal disorders.
Cyclooxygenase (Prostaglandin H synthase 1 and 2) inhibitor.

Caractéristiques et avantages

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogrammes

Health hazardExclamation mark
GHS08,GHS07

Mention d'avertissement

Danger

Mentions de danger

H302,H360

Classification des risques

Acute Tox. 4 Oral - Repr. 1A

Code de la classe de stockage

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

dust mask type N95 (US), Eyeshields, Gloves

Certificats d'analyse (COA)

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Naproxen Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1040

Naproxen

Naproxen United States Pharmacopeia (USP) Reference Standard

USP

1457301

Naproxen

L-(−)-Xylose, mixture of anomers ≥99%

Sigma-Aldrich

851590

L-(−)-Xylose, mixture of anomers

Naproxen 98%

Sigma-Aldrich

284785

Naproxen

Ketoprofen ≥98% (TLC)

Sigma-Aldrich

K1751

Ketoprofen

Diclofenac sodium salt

Sigma-Aldrich

D6899

Diclofenac sodium salt

Sulindac ≥98.0%

Sigma-Aldrich

S8139

Sulindac

Ibuprofen sodium salt ≥98% (GC)

Supelco

I1892

Ibuprofen sodium salt

Binding thermodynamics of Diclofenac and Naproxen with human and bovine serum albumins: A calorimetric and spectroscopic study
Bou-Abdallah F, et al.
The Journal of Chemical Thermodynamics, 103, 299-309 (2016)
Margarita Valero et al.
Langmuir : the ACS journal of surfaces and colloids, 26(13), 10561-10571 (2010-05-15)
The associative structures between F127 Pluronic micelles and four drugs, namely, lidocaine (LD), pentobarbital sodium salt (PB), sodium naproxen (NP), and sodium salicylate (SAL), were studied by small-angle neutron scattering (SANS). Different outcomes for the micellar aggregates are observed, which
Arın Gül Dal et al.
Journal of analytical methods in chemistry, 2014, 352698-352698 (2014-10-09)
Simple and rapid capillary zone electrophoretic method was developed and validated in this study for the determination of piroxicam in tablets. The separation of piroxicam was conducted in a fused-silica capillary by using 10 mM borate buffer (pH 9.0) containing 10%
Matteo Morotti et al.
European journal of obstetrics, gynecology, and reproductive biology, 179, 63-68 (2014-06-27)
Evaluate patient satisfaction at 6-month treatment in women with symptomatic rectovaginal endometriosis and migraine without aura with (progestogen-only contraceptive pill, POP versus sequential combined oral contraceptives, COC) STUDY DESIGN: A patient preference trial including 144 women (82 in the group
Jason A Miranda et al.
PloS one, 9(8), e106108-e106108 (2014-08-27)
Sensory processing in the spinal cord during disease states can reveal mechanisms for novel treatments, yet very little is known about pain processing at this level in the most commonly used animal models of articular pain. Here we report a
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Chromatograms

application for HPLC

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