K1751

Ketoprofen

≥98% (TLC), powder, non-steroidal anti-inflammatory compound

• Synonyme(s) : 2-(3-Benzoylphenyl)propionic acid
• Formule empirique (notation de Hill): C₁₆H₁₄O₃
• Numéro CAS: 22071-15-4
• Poids moléculaire : 254.28
• Numéro CE : 244-759-8
• Numéro MDL: MFCD00055790
• Code UNSPSC : 12352200
• ID de substance PubChem : 57654315
• Nomenclature NACRES : NA.77

Propriétés

• product name: Ketoprofen, ≥98% (TLC)
• Source biologique: synthetic
• Pureté: ≥98% (TLC)
• Forme: powder
• Solubilité: ethanol: 50 mg/mL, clear, colorless to yellow
• Auteur: Bayer
• Chaîne SMILES: CC(C(O)=O)c1cccc(c1)C(=O)c2ccccc2
• InChI: 1S/C16H14O3/c1-11(16(18)19)13-8-5-9-14(10-13)15(17)12-6-3-2-4-7-12/h2-11H,1H3,(H,18,19)
• Clé InChI: DKYWVDODHFEZIM-UHFFFAOYSA-N
• Informations sur le gène: human ... ALB(213) , IL8RA(3577) , PTGS1(5742) , PTGS2(5743)

Description

Description générale

Ketoprofen belongs to the class of 2-arylpropionic acid.

Application

Ketoprofen has been used:

• as sample to analyse the effects of long storage period by chromatographic and microscopic techniques
• as a nonselective COX inhibitor to inject subcutaneously in rats to study its effect on stress/methamphetamine hydrochloride-induced changes in occludin, claudin-5 and COX-2 protein immunoreactivity, truncation of β-dystroglycan, brain water content and fluorescein isothiocyanate-dextran extravasation
• in phosphate buffer to study its ability to inhibit heat-induced denaturation of albumin

Actions biochimiques/physiologiques

It serves as an efficient drug to treat ankylosing spondylitis, rheumatoid arthritis and osteoarthritis. It also has antipyretic and analgesic effects. Ketoprofen prevents the action of prostaglandin synthetase.

Composé anti-inflammatoire non stéroïdien spécifique de la COX-1.

Caractéristiques et avantages

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informations sur la sécurité

• Pictogrammes: GHS06,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H301,H315,H319,H400
• Conseils de prudence: P264 - P273 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Classification des risques: Acute Tox. 3 Oral - Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 2
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges