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L2023

Sigma-Aldrich

Leupeptin trifluoroacetate salt

powder, ≥90% (HPLC)

Synonyme(s) :

Acetyl-Leu-Leu-Arg-al trifluoroacetate salt

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About This Item

Formule empirique (notation de Hill) :
C20H38N6O4 · xC2HF3O2
Numéro CAS:
147385-61-3
Poids moléculaire :
426.55 (free base basis)
Numéro MDL:
MFCD00133458
Code UNSPSC :
12352202
ID de substance PubChem :
329817397
Nomenclature NACRES :
NA.77

Nom du produit

Leupeptin trifluoroacetate salt, ≥90% (HPLC), microbial

Source biologique

microbial

Niveau de qualité

200

Essai

≥90% (HPLC)

Forme

powder

Solubilité

H2O: 10 mM (Solutions are stable only a few hours. Stock solutions are stable up to 6 months at −20 °C.)

Température de stockage

−20°C

Chaîne SMILES 

OC(=O)C(F)(F)F.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O

InChI

1S/C20H38N6O4.C2HF3O2/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;3-2(4,5)1(6)7/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);(H,6,7)/t15-,16-,17-;/m0./s1

Clé InChI

WUHGBZVQELGOMH-FRKSIBALSA-N

Actions biochimiques/physiologiques

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM.
Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)

Remarque sur l'analyse

Leupeptin gives multiple peaks on HPLC because of the formation of tautomeric isomers in solution. Majority of contaminating peptide is racemized leupeptin.

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Équipement de protection individuelle

Eyeshields, Gloves, type N95 (US)

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Certificats d'analyse (COA)

Lot/Batch Number
039M4135V
50181202
058M4020V
50161203
SLBR0076V

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Maryam Amirazodi et al.
Iranian journal of basic medical sciences, 25(2), 254-262 (2022-06-04)
High-intensity interval training (HIIT) is a shape of interval training that provides ameliorated athletic capacity and has a good effect on health. Resveratrol is a natural polyphenol abundant in grapes and red wine and has been demonstrated to apply various
Javier Manzano-Lopez et al.
PloS one, 17(2), e0263617-e0263617 (2022-02-11)
Intracellular trafficking through the secretory organelles depends on transient interactions between cargo proteins and transport machinery. Cytosolic coat protein complexes capture specific luminal cargo proteins for incorporation into transport vesicles by interacting with them indirectly through a transmembrane adaptor or
John Cherrington Carmen et al.
Frontiers in microbiology, 2, 1-1 (2011-07-01)
The regulation of mitochondrial permeability, a key event in the initiation of apoptosis is governed by the opposing actions of the pro- and anti-apoptotic members of the BCL2-family of proteins. The BCL2-family can be classified further based on the number
Claudia Unterberger et al.
Molecular immunology, 45(11), 3230-3237 (2008-04-12)
In the present report we have determined the molecular mechanisms, which govern the expression of the human IL-10 gene when induced by the glucocorticoid Methyl-Prednisolone (MP). Treatment of cells with MP at 10(-6) M will readily induce IL-10 in CD19+
Cellular expression and antimicrobial function of a phylogenetically conserved novel histone 1x-like protein on mouse cells: a potential new class of pattern recognition receptor.
Evans, D.L., et al.
Journal of Neurochemistry, 86, 133-141 (2009)
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