SMB00932

2-Deoxy-D-glucose 6-phosphate sodium salt

≥98% (HPLC)

• Synonyme(s) : 2-Deoxy-D-glucose 6-phosphate sodium salt
• Formule empirique (notation de Hill): C₆H₁₃O₈P · xNa⁺
• Numéro CAS: 33068-19-8
• Poids moléculaire : 244.14 (free acid basis)
• Numéro MDL: MFCD00057477
• Code UNSPSC : 12352201
• Nomenclature NACRES : NA.25

Propriétés

• Niveau de qualité: 100
• Pureté: ≥98% (HPLC)
• Forme: powder
• Couleur: white
• Solubilité: water: 50 mg/mL, clear, colorless
• Température de stockage: −20°C
• Chaîne SMILES: [Na].OC(COP(O)(O)=O)C(O)C(O)CC=O
• InChI: 1S/C6H13O8P.Na.H/c7-2-1-4(8)6(10)5(9)3-14-15(11,12)13;;/h2,4-6,8-10H,1,3H2,(H2,11,12,13);;
• Clé InChI: NBDKYLFTCAOTAK-UHFFFAOYSA-N

Description

Description générale

2-Deoxy-D-glucose 6-phosphate sodium salt serves as a crucial intermediate in glycogen degradation. Its production in mammalian cells occurs through the action of hexokinase on 2-Deoxy-D-glucose (2-DG).

2-Deoxy-d-glucose (2DG) is a glucose molecule which has the 2-hydroxyl group replaced by hydrogen, so that it cannot undergo further glycolysis. As such, it acts to competitively inhibit the production of glucose-6-phosphate from glucose at the phosphoglucoisomerase level (step 2 of glycolysis). In most cells, glucose hexokinase phosphorylates 2-deoxyglucose, trapping the product 2-deoxyglucose-6-phosphate (2DG6P) intracellularly. 2DG & 2DG6P serve as good markers for tissue glucose uptake and hexokinase activity. For example, many cancers have elevated glucose uptake and hexokinase levels. 2DG6P undergoes only the first enzymatic reaction in the pentose phosphate pathway to generate 2-DG-6-phosphogluconolactone, which cannot be further metabolized.

Application

2-Deoxy-D-glucose 6-phosphate sodium salt is a versatile compound that finds application in metabolomics and biochemical research.

Caractéristiques et avantages

• High-purity compound suitable for a wide variety of research applications

Autres remarques

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Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable