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M0200000

D-Mannitol

European Pharmacopoeia (EP) Reference Standard

Synonyme(s) :

Mannitol

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About This Item

Formule empirique (notation de Hill):
C6H14O6
Numéro CAS:
69-65-8
Poids moléculaire :
182.17
Numéro Beilstein :
1721898
Numéro MDL:
MFCD00064287
Code UNSPSC :
41116107
ID de substance PubChem :
329817740
Nomenclature NACRES :
NA.24

Qualité

pharmaceutical primary standard

Famille d'API

mannitol

Fabricant/nom de marque

EDQM

Pf

167-170 °C (lit.)

Application(s)

pharmaceutical (small molecule)

Format

neat

Chaîne SMILES 

OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO

InChI

1S/C6H14O6/c7-1-3(9)5(11)6(12)4(10)2-8/h3-12H,1-2H2/t3-,4-,5-,6-/m1/s1

Clé InChI

FBPFZTCFMRRESA-KVTDHHQDSA-N

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Catégories apparentées

Description générale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets, has been developed and issued under the Authority of the Issuing Pharmacopoeia.

For further information and support please go to the website of the issuing Pharmacopoeia.

Application

This European Pharmacopoeia reference standard is intended for use only as specifically prescribed in the European Pharmacopoeia. Their suitability for any other use is not guaranteed and is the sole responsibility of the user. This standard is not intended for human or animal use.
Established for the preparation of the below-given solutions as per European Pharmacopoeia:

  • Reference solution (b) in the testing of related substances using liquid chromatography (General text 2.2.29) in isomalt, according to the monograph 1531
  • Reference solutions (a) in the identification of mannitol using thin-layer chromatography (General text 2.2.27) and infra-red spectroscopy and testing of related substances and assay using liquid chromatography (General text 2.2.29), according to the monograph 0559
  • Reference solution (b) in the identification of sorbitol using thin-layer chromatography (General text 2.2.27), according to the monograph 0435
  • Reference solution (b) in the testing of related substances using gas chromatography (General text 2.2.28), according to the monograph 1381

Actions biochimiques/physiologiques

Agent de sapidité sucré constitué de sucre d′alcool. Utilisé dans les études d′inhibition du goût sucré.

Conditionnement

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Autres remarques

Sales restrictions may apply.

Produit(s) apparenté(s)

Réf. du produit
Description
Tarif

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 1

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Certificats d'analyse (COA)

Lot/Batch Number

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Retrouvez la documentation relative aux produits que vous avez récemment achetés dans la Bibliothèque de documents.

Consulter la Bibliothèque de documents

Sorbitol
European Pharmacopoeia Commission and European Directorate for the Quality of Medicines & Healthcare
European pharmacopoeia, 3865-3867 (2019)
Heikki O Koskela et al.
Chest, 124(6), 2171-2177 (2003-12-11)
To compare a new bronchial provocation test, the mannitol challenge, with cold air and histamine challenges to demonstrate airway hyperresponsiveness (AHR) in patients with difficult-to-diagnose asthma. A prospective study. Thirty-seven consecutive patients with recently diagnosed, steroid-naive, mild, or atypical asthma
Heikki O Koskela et al.
Chest, 125(6), 1985-1992 (2004-06-11)
To define whether coughing during mannitol challenge is a nonspecific side effect of this challenge or is associated with asthma. A prospective study. University hospital. Thirty-seven steroid-naive, asthmatic subjects and 10 healthy subjects. The participants completed a symptom questionnaire, recorded
Heikki O Koskela et al.
Chest, 124(4), 1341-1349 (2003-10-14)
To compare the sensitivity and validity of mannitol, histamine, and cold air challenges to demonstrate the effect of inhaled corticosteroids (ICS) in asthma. A prospective study. Seventeen patients with recently diagnosed, steroid-naive asthma who fulfilled the diagnostic criteria of Finnish
Diana Bilton et al.
Thorax, 69(12), 1073-1079 (2014-09-24)
Bronchiectasis is characterised by excessive production of mucus and pulmonary exacerbations. Inhaled osmotic agents may enhance mucociliary clearance, but few long-term clinical trials have been conducted. To determine the impact of inhaled mannitol on exacerbation rates in patients with non-cystic
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