52332
Phenylmethylsulfonyl Fluoride
Phenylmethylsulfonyl Fluoride, CAS 329-98-6, is an irreversible inhibitor of serine proteases. It causes sulfonylation of the active-site serine residues.
Synonyme(s) :
Phenylmethylsulfonyl Fluoride, Benzylsulfonyl Fluoride, PMSF
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About This Item
Formule empirique (notation de Hill):
C7H7FO2S
Numéro CAS:
Poids moléculaire :
174.19
Numéro MDL:
Code UNSPSC :
12352202
Nomenclature NACRES :
NA.77
Produits recommandés
Niveau de qualité
Pureté
≥99% (GC)
Forme
crystalline solid
Fabricant/nom de marque
Calbiochem®
Conditions de stockage
OK to freeze
desiccated
Couleur
white to off-white
Solubilité
ethanol: soluble
isopropanol: soluble
methanol: soluble
Conditions d'expédition
ambient
Température de stockage
10-30°C
InChI
1S/C7H7FO2S/c8-11(9,10)6-7-4-2-1-3-5-7/h1-5H,6H2
Clé InChI
YBYRMVIVWMBXKQ-UHFFFAOYSA-N
Description générale
Irreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. Effective at a concentration of 50 µM.
Irreversible inhibitor of serine proteases. Its mechanism of action is analogous to that of diisopropylfluorophosphate. PMSF causes sulfonylation of the active-site serine residues. Also reported to inhibit internucleosomal DNA fragmentation in immature thymocytes. For a related, more stable inhibitor, see AEBSF (Cat. No. 101500).
Actions biochimiques/physiologiques
Cell permeable: no
Primary Target
serine proteases
serine proteases
Product does not compete with ATP.
Reversible: no
Avertissement
Toxicity: Corrosive (L)
Reconstitution
Following reconstitution, refrigerate (4°C). Stock solutions are stable for up to 9 months at 4°C.
t½ = 1 hour at pH 7.5. Effective concentration: 50 μM.
Autres remarques
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Seitz, R., et al. 1993. Int. J. Cancer53, 514.
Weaver, V.M., et al. 1993. Biochem. Cell. Biol.71, 488.
Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol.316, 427.
Chang, C.T., et al. 1992. Biochem. Int.28, 707.
Weaver, V.M., et al. 1993. Biochem. Cell. Biol.71, 488.
Bourgain, R.H., et al. 1992. Adv. Exp. Med. Biol.316, 427.
Chang, C.T., et al. 1992. Biochem. Int.28, 707.
Informations légales
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Mention d'avertissement
Danger
Mentions de danger
Classification des risques
Acute Tox. 3 Oral - Skin Corr. 1B
Code de la classe de stockage
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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