T8826

Terbinafine hydrochloride

• Sinónimos: trans-N-(6,6-Dimethyl-2-hepten-4-ylyl)-N-methyl-1-naphthylmethylamine hydrochloride
• Fórmula empírica (notación de Hill): C₂₁H₂₅N · HCl
• Número de CAS: 78628-80-5
• Peso molecular: 327.89
• Número MDL: MFCD00145430
• Código UNSPSC: 51302503
• ID de la sustancia en PubChem: 329826887
• NACRES: NA.85

Propiedades

• Análisis: ≥98%
• formulario: powder
• color: white to faint beige
• solubilidad: methanol: soluble 50 mg/mL
• espectro de actividad antibiótica: fungi; yeast
• Modo de acción: enzyme | inhibits
• cadena SMILES: Cl[H].[H]\C(CN(C)Cc1cccc2ccccc12)=C(\[H])C#CC(C)(C)C
• InChI: 1S/C21H25N.ClH/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19;/h5-7,9-14H,16-17H2,1-4H3;1H/b9-5+;
• Clave InChI: BWMISRWJRUSYEX-SZKNIZGXSA-N

Descripción

Descripción general

Allylamine derivative.

Aplicación

Terbinafine hydrochloride is a synthetic allylamine antifungal. It is used to treat dermatophyte infections of the toenail/fingernail, ringworm and jock itch. It is used in adsorption, partition and stability studies.

Acciones bioquímicas o fisiológicas

Mode of Action: Inhibits squalene epoxidase, preventing biosynthesis of ergosterol.Antimicrobial spectrum: Antifungal and antimycotic. Fungicidal against dermatopytes and some yeasts; fungistatic against Candida albicans.

Terbinafine inhibits squalene monooxygenase thereby blocking the biosynthesis of ergosterol, which is an essential component of fungal cell membranes. The inhibition of squalene monooxygenase also results in the accumulation of squalene. Terbinafine hydrochloride is highly lipophilic and tends to accumulate in skin, nails, and fatty tissues. It is antifungal and antimycotic. It is fungicidal against dermatopytes and some yeasts and is fungistatic against Candida albicans.

Otras notas

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Cláusula de descargo de responsabilidad

The product is not intendedfor use as a biocide under global biocide regulations, including but notlimited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, EuropeanBiocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’sBiocidal Products Regulation, Korea’s Consumer Chemical Products and BiocideSafety Management Act (K-BPR) and others.

Información de seguridad

• Pictogramas: GHS07,GHS09
• Palabra de señalización: Warning
• Frases de peligro: H315,H319,H335,H410
• Consejos de prudencia: P261 - P264 - P271 - P273 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Equipo de protección personal: dust mask type N95 (US), Eyeshields, Gloves