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T7165

Sigma-Aldrich

Tyrphostin 23

≥98%

Sinónimos:

(3,4-Dihydroxybenzylidene)malononitrile, RG-50810

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About This Item

Fórmula empírica (notación de Hill):
C10H6N2O2
Número de CAS:
118409-57-7
Peso molecular:
186.17
Número MDL:
MFCD00133899
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24278041
NACRES:
NA.77

origen biológico

synthetic (organic)

Análisis

≥98%

formulario

powder

potencia

35 μM IC50

solubilidad

DMSO: soluble 50 mg/mL, clear, yellow to brownish-yellow

temp. de almacenamiento

2-8°C

cadena SMILES

Oc1ccc(cc1O)\C=C(\C#N)C#N

InChI

1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H

Clave InChI

VTJXFTPMFYAJJU-UHFFFAOYSA-N

Información sobre el gen

human ... CDK2(1017)

Aplicación

Tyrphostin 23 can be used as a tyrosine kinase inhibitor for studying rat ghrelin-induced MAPK stimulation in GH3 cells. Tyrphostin 23 has also been used to analyze its effects on secretoneurin (SN)-induced chemotaxis of neutrophils.

Acciones bioquímicas o fisiológicas

Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain,.

Características y beneficios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Brefeldin A (BFA) is a useful tool for studying protein trafficking and identifying organelles in the plant secretory and endocytic pathways. At low concentrations (5-10 microg ml(-1)), BFA caused both the Golgi apparatus and trans-Golgi network (TGN), an early endosome
Masaru Fujimoto et al.
Proceedings of the National Academy of Sciences of the United States of America, 107(13), 6094-6099 (2010-03-17)
Endocytosis performs a wide range of functions in animals and plants. Clathrin-coated vesicle (CCV) formation is an initial step of endocytosis, and in animal cells is largely achieved by dynamins. However, little is known of its molecular mechanisms in plant
E Heim
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