SML0635

AZD6765 dihydrochloride

≥97% (HPLC)

• Sinónimos: (αS)-α-Phenyl-2-pyridineethanamine dihydrochloride, AR-R 15896 dihydrochloride, FPL 15896 dihydrochloride, Lanicemine dihydrochloride
• Fórmula empírica (notación de Hill): C₁₃H₁₄N₂ · 2HCl
• Número de CAS: 153322-06-6
• Peso molecular: 271.19
• Código UNSPSC: 12352200
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥97% (HPLC)
• formulario: powder
• actividad óptica: [α]/D +77 to +90°, c = 1 in methanol
• condiciones de almacenamiento: desiccated
• color: white to beige
• solubilidad: H₂O: 20 mg/mL, clear
• temp. de almacenamiento: 2-8°C
• InChI: 1S/C13H14N2.2ClH/c14-13(11-6-2-1-3-7-11)10-12-8-4-5-9-15-12;;/h1-9,13H,10,14H2;2*1H/t13-;;/m0../s1
• Clave InChI: KHJHFYAGQZYCLC-GXKRWWSZSA-N

Descripción

Aplicación

AZD6765 dihydrochloride has been used as an antidepressant to improve behavior and metabolic measures in chronic unpredictable mild stress (CUMS).

Acciones bioquímicas o fisiológicas

AZD6765 is a noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist and fast-acting antidepressant. In a recent study AZD6765 relieved depression within 80 minutes, unlike most antidepressants acting on serotonin or dopamine systems which can take several weeks to work. The effects lasted from about an hour up to 2 weeks. AZD6765 has an IC₅₀ value of 1.3 μM. Unlike more potent drugs such as ketamine, which also has rapid antidepressant activity, AZD6765 has no dissociative side-effects such as hallucinations. Earlier studies inidcated the compound has neuroprotective and anticonvulsant effects.

Características y beneficios

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Pictogramas: GHS06
• Palabra de señalización: Danger
• Frases de peligro: H301
• Consejos de prudencia: P264 - P270 - P301 + P310 - P405 - P501
• Clasificaciones de peligro: Acute Tox. 3 Oral
• Código de clase de almacenamiento: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable