T3634

(+)-α-Tocopherol

from vegetable oil, Type V, ~1000 IU/g

• Sinónimos: 2,5,7,8-Tetramethyl-2-(4′,8′,12′-trimethyltridecyl)-6-chromanol, 5,7,8-Trimethyltocol, D-α-Tocopherol, Vitamin E
• Fórmula empírica (notación de Hill): C₂₉H₅₀O₂
• Número de CAS: 59-02-9
• Peso molecular: 430.71
• Beilstein: 4712525
• Número CE: 200-412-2
• Número MDL: MFCD00072045
• Código UNSPSC: 12352205
• eCl@ss: 34058016
• ID de la sustancia en PubChem: 24900154
• NACRES: NA.79

Propiedades

• origen biológico: vegetable oil
• Nivel de calidad: 200
• tpo: Type V
• Formulario: viscous liquid
• actividad específica: ~1000 IU/g
• color: clear yellow to red
• índice de refracción: n20/D 1.505 (lit.)
• bp: 200-220 °C/0.1 mmHg (lit.)
• densidad: 0.95 g/mL at 25 °C (lit.)
• temp. de almacenamiento: −20°C
• cadena SMILES: CC(C)CCC[C@@H](C)CCC[C@@H](C)CCC[C@]1(C)CCc2c(C)c(O)c(C)c(C)c2O1
• InChI: 1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3/t21-,22-,29-/m1/s1
• Clave InChI: GVJHHUAWPYXKBD-IEOSBIPESA-N

Descripción

Descripción general

α-Tocopherol is synthesized from γ-tocopherol by the action of enzyme γ-tocopherol methyltransferase. It is the major form of Vitamin E in human plasma. It is present in sunflower seed oil.

Aplicación

(+)-α-Tocopherol has been used:

• as a food supplement for juvenile cobia fish
• to evaluate its protective effect on bisphenol A induced oxidative stress in rats
• to test its chemopreventive efficacy in estrogen-mediated mammary cancer rats

Acciones bioquímicas o fisiológicas

α-Tocopherol is essential for the photosynthesis in Synechocystis sp. strain PCC 6803. Supplementation with α-Tocopherol decreases lipid peroxidation and platelet aggregation. It inhibits protein kinase C and may play key role in gene regulation.

Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Various isofroms and analogues of tocopherol have opposing and differentiated regulatory activities in vivo.

Envase

Packaged under argon in a sealed ampule.

Otras notas

Mixed constitutional (α, β, γ, δ) isomers.

Calidad

Approx. 670 mg D-α-tocopherol per gram. The non-α content is typically between 5-35 mg/g

Precaución

Subject to air oxidation.

Propiedades físicas

This product is miscible with chloroform or ethanol. It is practically insoluble in water but it is miscible with ether, acetone, and vegetable oils. It is unstable to alkaline conditions.

Información de seguridad

• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): 230.0 °F - closed cup
• Punto de inflamabilidad (°C): 110 °C - closed cup
• Equipo de protección personal: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)