258024

(±)-α-Tocoferol

≥95.5%

• Sinónimos: DL-todo-rac-α-Tocoferol, Vitamina E
• Fórmula empírica (notación de Hill): C₂₉H₅₀O₂
• Número de CAS: 10191-41-0
• Peso molecular: 430.71
• Beilstein: 94012
• Número CE: 233-466-0
• Número MDL: MFCD00006848
• Código UNSPSC: 12352205
• eCl@ss: 34058016
• ID de la sustancia en PubChem: 57648149

Propiedades

• origen biológico: synthetic
• Nivel de calidad: 200
• Análisis: ≥95.5%
• formulario: liquid
• técnicas: HPLC: suitable
• color: faint brown to brown; yellow to very dark yellow
• densidad: 0.950 g/mL at 20 °C (lit.)
• aplicaciones: cell analysis
• temp. de almacenamiento: 2-8°C
• cadena SMILES: CC(C)CCCC(C)CCCC(C)CCCC1(C)CCc2c(C)c(O)c(C)c(C)c2O1
• InChI: 1S/C29H50O2/c1-20(2)12-9-13-21(3)14-10-15-22(4)16-11-18-29(8)19-17-26-25(7)27(30)23(5)24(6)28(26)31-29/h20-22,30H,9-19H2,1-8H3
• Clave InChI: GVJHHUAWPYXKBD-UHFFFAOYSA-N

Descripción

Descripción general

α-Tocopherol is the active form of vitamin E. It functions as an hydroperoxyl radical scavenger and protects the organism from oxidative damage. α-Tocopherol plays a crucial role in cell signalling and regulating immune responses. α-Tocopherol deficiency is associated with abetalipoproteinemia, cystic fibrosis and celiac disease. It has antiproliferative effects. It inhibits arsenite-induced damage of human fibroblasts.

Aplicación

α-Tocopherol has been used:

• as a standard to determine its concentration by reverse-phase high-performance liquid chromatography
• to study its rescue effects on chlorine dioxide (ClO₂) cytotoxicity
• to assess its protective effects on acetaminophen (APAP)-mediated liver damage

Acciones bioquímicas o fisiológicas

Tocopherols (TCP) (vitamin E) are a series (α, β, γ and δ) of chiral organic molecules that vary in their degree of methylation of the phenol moiety of the chromanol ring. Tocopherols are lipid soluble anti-oxidants that protect cell membranes from oxidative damage. α-Tocopherol is the form of tocopherol preferentially absorbed by homo sapiens. Various isofroms and analogues of tocopherol have opposing and differentiated regulatory activities in vivo.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H317
• Consejos de prudencia: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Clasificaciones de peligro: Skin Sens. 1
• Código de clase de almacenamiento: 10 - Combustible liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Equipo de protección personal: Eyeshields, Gloves