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T3573

Sigma-Aldrich

RANK Ligand/TRANCE human

>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder

Sinónimos:

Osteoclast Differentiation Factor (ODF), Osteoprotegerin Ligand (OPGL), Receptor Activator of NF-KB Ligand (RANKL), TNF-related activation-induced cytokines (TRANCE)

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About This Item

Número de CAS:
207621-35-0
Número MDL:
MFCD01867142
Código UNSPSC:
12352202
NACRES:
NA.32

origen biológico

human

Nivel de calidad

200

recombinante

expressed in NSO cells

Análisis

>90% (SDS-PAGE)

formulario

lyophilized powder

potencia

1.5-7.5 ng/mL ED50

mol peso

glycolysylated recombinant product ~35 kDa by SDS-PAGE
calculated mol wt 23 kDa

envase

pkg of 10 μg

condiciones de almacenamiento

avoid repeated freeze/thaw cycles

impurezas

endotoxin, tested

Nº de acceso UniProt

O14788

aplicaciones

cell analysis

temp. de almacenamiento

−20°C

Información sobre el gen

human ... TNFSF11(8600)

Categorías relacionadas

Descripción general

Tumor necrosis factor (ligand) superfamily, member 11 (Tnfsf11) is also known as receptor activator of nuclear factor-κB ligand (RANKL). It is a type II transmembrane signaling receptor. It has a molecular weight of around 35kDa. This protein contains an amino-terminal intracellular tail and a carboxy-terminal extracellular region, that bears a connecting stalk and a receptor-binding domain. Tnfsf11 is located on human chromosome 13q14.11.

Aplicación

RANK Ligand/TRANCE human can be used in in vitro osteoclastogenic assays for osteoclast differentiation.
RANK Ligand/TRANCE human has been used to stimulate differentiation.

Acciones bioquímicas o fisiológicas

RANK Ligand (receptor activator of NF-kB ligand (RANKL) also referred to as TNF-related activation induced cytokines (TRANCE) or osteoprotegerin ligand is a protein that belongs to tumor necrosis factor (TNF) family. It stimulates the mature dendritic cells and induces the cytokine production. RANKL also facilitates bone remodelling and possess an angiogenic activity.
RANK Ligand/TRANCE, a member of the TNF superfamily, induces activation of the c-jun N-terminal kinase, enhances T-cell growth and dendritic cell function, induces osteoclastogenesis, and lymph node organogenesis. Mouse and human RANK Ligand share 85% amino acid identity. RANK is the cell surface receptor for RANK Ligand.

Forma física

Lyophilized from a 0.2 μm filtered solution in 20 mM MOPS and 500 mM NaCl, pH 6.5, with 50 μg BSA per 1 μg as a carrier protein.

Nota de análisis

The biological activity is measured by its ability to induce osteoclast differentiation on mouse splenocytes.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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RANKL employs distinct binding modes to engage RANK and the osteoprotegerin decoy receptor
Nelson C A, et al.
Structure, 20(11), 1971-1982 (2012)
Matrine prevents bone loss in ovariectomized mice by inhibiting RANKL-induced osteoclastogenesis
Chen X, et al.
Faseb Journal, 31(11), 4855-4865 (2017)
Jeong-Ki Min et al.
The Journal of biological chemistry, 278(41), 39548-39557 (2003-08-02)
Vascular endothelial growth factor (VEGF) is known as a key regulator of angiogenesis during endochondral bone formation. Recently, we demonstrated that TNF-related activation-induced cytokine (TRANCE or RANKL), which is essential for bone remodeling, also had an angiogenic activity. Here we
Cytosolic phospholipase A2 and eicosanoids modulate life, death and function of human osteoclasts in vitro
Allard-Chamard H, et al.
Prostaglandins, Leukotrienes, and Essential Fatty Acids, 90(4), 117-123 (2014)
R Josien et al.
Journal of immunology (Baltimore, Md. : 1950), 162(5), 2562-2568 (1999-03-11)
TNF-related activation-induced cytokine (TRANCE) is a member of the TNF family recently identified in activated T cells. We report here that TRANCE mRNA is constitutively expressed in memory, but not naive, T cells and in single-positive thymocytes. Upon TCR/CD3 stimulation
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