T2455

T3MG

• Sinónimos: (±)-threo-3-Methylglutamic acid, 3MG, threo-3-Methylglutamate
• Fórmula empírica (notación de Hill): C₆H₁₁NO₄
• Número de CAS: 63088-04-0
• Peso molecular: 161.16
• Número MDL: MFCD09836097
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329826708
• NACRES: NA.77

Propiedades

• Formulario: powder
• Nivel de calidad: 100
• color: white to off-white
• solubilidad: H₂O: >1.5 mg/dL
• idoneidad: suitable for TLC (single spot)
• temp. de almacenamiento: room temp
• cadena SMILES: C[C@@H](CC(O)=O)[C@@H](N)C(O)=O
• InChI: 1S/C6H11NO4/c1-3(2-4(8)9)5(7)6(10)11/h3,5H,2,7H2,1H3,(H,8,9)(H,10,11)/t3-,5+/m0/s1
• Clave InChI: FHJNAFIJPFGZRI-WVZVXSGGSA-N

Descripción

Acciones bioquímicas o fisiológicas

T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4.

T3MG is a selective inhibitor of excitatory amino acid transporters GLT-1, EAAT2, and EAAT4. T3MG has long been utilized as a gold standard in the study of general EAAT function. It has more recently been shown to be selective for EAAT2 and EAAT4 as compared to EAAT1 and EAAT3 in electrophysiology and glutamate/aspartate uptake assays. Although there are other EAAT2-selective compounds, this is the first tool with selectivity for EAAT4. T3MG is not a substrate for the transporters themselves, nor does it have activity at glutamate ion channels.

Características y beneficios

This compound is featured on the Excitatory Amino Acid Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Nota de preparación

T3MG dissolves in water at a concentration that is greater than 1.5 mg/ml.

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319,H335
• Consejos de prudencia: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órganos de actuación: Respiratory system
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable