T0826
TBB
≥98% (HPLC), solid
Sinónimos:
4,5,6,7-Tetrabromo-2-azabenzimidazole, 4,5,6,7-Tetrabromobenzotriazole, NSC 231634, TBBt
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About This Item
Fórmula empírica (notación de Hill):
C6HN3Br4
Número de CAS:
Peso molecular:
434.71
Número MDL:
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
NACRES:
NA.77
Productos recomendados
Nivel de calidad
Ensayo
≥98% (HPLC)
Formulario
solid
color
white
solubilidad
DMSO: 28 mg/mL
temp. de almacenamiento
2-8°C
cadena SMILES
Brc1c(Br)c(Br)c2[nH]nnc2c1Br
InChI
1S/C6HBr4N3/c7-1-2(8)4(10)6-5(3(1)9)11-13-12-6/h(H,11,12,13)
Clave InChI
OMZYUVOATZSGJY-UHFFFAOYSA-N
Categorías relacionadas
Aplicación
TBB was used to study casein kinase 2-dependent phosphorylation of DNA damage mediator protein MDC1.
Acciones bioquímicas o fisiológicas
TBB binds to the Val66 residue of casein kinase-2 and inhibits the binding of ATP/GTP. TBB is cell permeable; it induces caspase-dependent apoptosis and degrades hematopoietic lineage cell-specific protein 1 in Jurkat cells.
TBB is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2) (IC50 = 900 nM and 1.6 mM, using rat liver and recombinant human CK2, respectively).
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
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Los clientes también vieron
S Sarno et al.
FEBS letters, 496(1), 44-48 (2001-05-10)
The specificity of 4,5,6,7-tetrabromo-2-azabenzimidazole (TBB), an ATP/GTP competitive inhibitor of protein kinase casein kinase-2 (CK2), has been examined against a panel of 33 protein kinases, either Ser/Thr- or Tyr-specific. In the presence of 10 microM TBB (and 100 microM ATP)
Maria Ruzzene et al.
The Biochemical journal, 364(Pt 1), 41-47 (2002-05-04)
Incubation of Jurkat cells with 4,5,6,7-tetrabromobenzotriazole (TBB), a specific inhibitor of protein kinase CK2, induces dose-and time-dependent apoptosis as judged by several criteria. TBB-promoted apoptosis is preceded by inhibition of Ser/Thr phosphorylation of haematopoietic lineage cell-specific protein 1 (HS1) and
J Ross Chapman et al.
EMBO reports, 9(8), 795-801 (2008-06-28)
Mammalian cells respond to DNA double-strand breaks (DSBs) by recruiting DNA repair and cell-cycle checkpoint proteins to such sites. Central to these DNA damage response (DDR) events is the DNA damage mediator protein MDC1. MDC1 interacts with several DDR proteins
Andrew W Bergen et al.
PloS one, 10(7), e0126113-e0126113 (2015-07-02)
The Nicotine Metabolite Ratio (NMR, ratio of trans-3'-hydroxycotinine and cotinine), has previously been associated with CYP2A6 activity, response to smoking cessation treatments, and cigarette consumption. We searched for drug metabolizing enzyme and transporter (DMET) gene variation associated with the NMR
Kate J Treharne et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 24(5-6), 347-360 (2009-11-17)
Deletion of phenylalanine-508 (DeltaF508) from the first nucleotide-binding domain (NBD1) in the wild-type cystic fibrosis (CF) transmembrane-conductance regulator (wtCFTR) causes CF. However, the mechanistic relationship between DeltaF508-CFTR and the diversity of CF disease is unexplained. The surface location of F508
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