SRP7783
MMP-3 human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE), ≥95% (HPLC)
Sinónimos:
EC 3, Matrix metalloproteinase-3, Stromelysin-1
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About This Item
Productos recomendados
origen biológico
human
recombinante
expressed in E. coli
Análisis
≥95% (HPLC)
≥95% (SDS-PAGE)
formulario
lyophilized
mol peso
~19.5 kDa
envase
pkg of 10 μg
técnicas
western blot (chemiluminescent): suitable
impurezas
endotoxin, tested
Nº de acceso NCBI
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Información sobre el gen
human ... MMP3(4314)
Descripción general
Active MMP-3 catalytic domain from human cDNA, expressed in E. coli and purified using proprietary technologies. The active MMP-3 is very useful in studying enzyme kinetics, cleave target substrates, and screen for inhibitors.
The gene JE is an early growth response gene that was first identified in mouse 3T3 cells. The gene is mapped to mouse chromosome 11. It encodes a member of the CC subfamily, the members of which contain characteristic two adjacent cysteine residues.
Aplicación
MCP-1 has been used to induce chemotaxis in mice macrophages.
MMP-3 human has been used to develop a simple and sensitive electrogenerated chemiluminescence (electrochemiluminescence (ECL)) peptide-based bioassay for the detection of matrix metalloproteinases releasing from living cells.
Acciones bioquímicas o fisiológicas
Matrix metallopeptidase 3 (MMP3) has a broad substrate specificity and is capable of degrading fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. It participates in wound repair, progression of atherosclerosis, tissue remodeling and tumor initiation. MMP3 variants can be associated with hypertrophy of interventricular septum or hypertrophic cardiomyopathy.
The gene JE, also referred to as MCP-1 (monocyte chemoattractant protein-1), encodes a secreted chemokine that functions as a chemoattractant for monocytes and may activate their anti-tumor properties. This protein may serve as a potential therapeutic anticancer agent.
Forma física
Lyophilized powder.
Reconstitución
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in sterile PBS to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Los clientes también vieron
Suppression of tumor formation in vivo by expression of the JE gene in malignant cells.
Rollins BJ and Sunday ME
Molecular and Cellular Biology, 11, 3125-3131 (1991)
Rowan Pentz et al.
Neurobiology of disease, 148, 105150-105150 (2020-11-02)
Matrix metalloproteinase-3 (MMP-3) has been associated with risk of Alzheimer's disease (AD). In this study we introduce a novel role for MMP-3 in degrading nerve growth factor (NGF) in vivo and examine its mRNA and protein expression across the continuum
Simple and sensitive electrogenerated chemiluminescence peptide-based biosensor for detection of matrix metalloproteinase 2 released from living cells
Dang Q, et al.
Analytical and Bioanalytical Chemistry, 408(25), 7067-7075 (2016)
J S Frieling et al.
Oncogene, 36(31), 4498-4507 (2017-04-04)
Parathyroid hormone-related protein (PTHrP) is a critical regulator of bone resorption and augments osteolysis in skeletal malignancies. Here we report that the mature PTHrP
Hematopoietic-Derived Galectin-3 Causes Cellular and Systemic Insulin Resistance.
Li P
Cell, 167, 973-984 (2016)
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