SRP5223
PAD1, GST tagged human
recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution
Sinónimos:
HPAD10, PADI1, PDI, PDI1
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About This Item
Código UNSPSC:
12352200
NACRES:
NA.32
Productos recomendados
origen biológico
human
recombinante
expressed in baculovirus infected Sf9 cells
Análisis
≥70% (SDS-PAGE)
formulario
buffered aqueous glycerol solution
mol peso
~95 kDa
Nº de acceso NCBI
aplicaciones
cell analysis
Condiciones de envío
dry ice
temp. de almacenamiento
−70°C
Información sobre el gen
human ... PADI1(29943)
Descripción general
Peptidyl arginine deiminase 1 (PAD1) is a member of the peptidyl arginine deiminase family of enzymes. It is a component of the 26S proteasome, a multiprotein complex that degrades proteins targeted for destruction by the ubiquitin pathway. PAD1 is expressed in the epidermis and uterus. The gene encoding this protein is localized on human chromosome 1p36.13.
Acciones bioquímicas o fisiológicas
Peptidyl arginine deiminases catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The overexpression of PAD1 induced a distinctive pattern of multidrug resistance in mammalian cells and moderate resistance to ultraviolet light. PAD1 is also responsible for substrate deubiquitination during proteasomal degradation. It deiminates filaggrin in the last stages of keratinocyte differentiation. Thus, PAD1 has a role in epidermis function and homeostasis. The protein has been genetically associated with rheumatoid arthritis.
Forma física
Supplied in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Nota de preparación
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
Nota de análisis
This protein is not assayed for enzymatic activity.
Código de clase de almacenamiento
10 - Combustible liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Citrullination of CXCL8 by peptidylarginine deiminase alters receptor usage, prevents proteolysis, and dampens tissue inflammation.
Proost P
The Journal of Experimental Medicine (2008)
Potential Role of Peptidylarginine Deiminase Enzymes and Protein Citrullination in Cancer Pathogenesis
Sunish Mohanan, et.la
Biochemistry Research International (2012)
The peptidylarginine deiminases expressed in human epidermis differ in their substrate specificities and subcellular locations.
Mechin MC
Cellular and Molecular Life Sciences (2005)
Identification of 45 novel SNPs in the 83-kb region containing peptidylarginine deiminase types 1 and 3 loci on chromosomal band 1p36.13.
Lida A and Nakamura Y
Journal of Human Genetics (2004)
Tingting Yao et al.
Nature, 419(6905), 403-407 (2002-09-28)
The 26S proteasome is responsible for most intracellular proteolysis in eukaryotes. Efficient substrate recognition relies on conjugation of substrates with multiple ubiquitin molecules and recognition of the polyubiquitin moiety by the 19S regulatory complex--a multisubunit assembly that is bound to
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