C7521
Human Collagen Type IV
from human placenta, powder, suitable for substrate for collagenase and for diagnostic assay manufacturing
Sinónimos:
Collagen Type 4
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About This Item
Productos recomendados
product name
Colágeno from human placenta, Bornstein and Traub Type IV, powder
origen biológico
human placenta
Nivel de calidad
descripción
Sigma Type VI
formulario
powder
impurezas
HIV, hepatitis B and hepatitis C, none detected
solubilidad
0.5 M acetic acid: 1 mg/mL
idoneidad
suitable for substrate for collagenase
aplicaciones
diagnostic assay manufacturing
temp. de almacenamiento
−20°C
Información sobre el gen
human ... COL4A2(1284) , COL4A3(1285) , COL4A4(1286) , COL4A5(1287) , COL4A6(1288)
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Acciones bioquímicas o fisiológicas
During development, collagen IV is ubiquitously distributed in BMs. During the maturation process, this network gets partially replaced in a remarkably tissue specific manner, defining BM structure and function. Collagen IV has been shown to bind to platelets, hepatocytes, keratinocytes, endothelial, mesangial, pancreatic cells and some tumor cells.
Componentes
All collagen molecules are composed of three polypeptide chains arranged in a triple helical conformation, with a primary structure that is mostly a repeating motif with glycine in every third position and proline or 4-hydroxyproline frequently preceding the glycine residue. Type IV collagen occurs only in the basement membranes and contains up to six genetically distinct a-chains.
Nota de preparación
This is a lyophilized powder that can be reconstituted in sterile .5 M acetic acid, PBS or water at 1 mg/mL. A PBS solution will be stable for at least one year at -20°C. It is prepared by a modification of the pepsin extraction method of Glanville, R.W., et al.
Nota de análisis
An SDS polyacrylamide gel electrophoresis test run under reducing conditions consistent with basement membrane collagen yields three major bands.
Otras notas
El colágeno se clasifica en una serie de distintos tipos desde el punto de vista estructural y genético. Nosotros utilizamos la nomenclatura propuesta por Bornstein y Traub. Tenga cuidado de no confundir las designaciones de tipo Sigma con los tipos de clasificación de colágeno reconocidos
Código de clase de almacenamiento
11 - Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
Equipo de protección personal
Eyeshields, Gloves, type N95 (US)
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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