SML0140

BV02

≥98% (HPLC)

• Sinónimos: 2-(2,3-Dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)-2,3-dihydro-1,3-dioxo-1H-isoindole-5-carboxylic acid
• Fórmula empírica (notación de Hill): C₂₀H₁₅N₃O₅
• Número de CAS: 292870-53-2
• Peso molecular: 377.35
• Número MDL: MFCD00356631
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825188
• NACRES: NA.77

Propiedades

• descripción: The structure of BV02 differs slightly from the published form, but has been internally verified by Sigma-Aldrich quality control.
• Nivel de calidad: 100
• Análisis: ≥98% (HPLC)
• formulario: powder
• color: white to off-white
• solubilidad: DMSO: >5 mg/mL
• temp. de almacenamiento: room temp
• cadena SMILES: CN1N(c2ccccc2)C(=O)C(N3C(=O)c4ccc(cc4C3=O)C(O)=O)=C1C
• InChI: 1S/C20H15N3O5/c1-11-16(19(26)23(21(11)2)13-6-4-3-5-7-13)22-17(24)14-9-8-12(20(27)28)10-15(14)18(22)25/h3-10H,1-2H3,(H,27,28)
• Clave InChI: ZFYSDSINNOLWGO-UHFFFAOYSA-N

Descripción

Aplicación

BV02 has been used to study the effects of 14-3-3σ on P-glycoprotein and pregnane X receptor protein xpression. It has also been used as a control in studying BAP1 (BRCA1 (breast cancer gene)-associated protein 1) inducing cell death via interaction with 14-3-3 in neuroblastoma.

BV02, an inhibitor of the 14-3-3 scaffolding protein docking sites, may be used to study the roles and functions of 14-3-3 scaffolding proteins in signaling pathways involved in the cell cycle, and processes such as apoptosis, stress response, and malignant cell transformation.

Acciones bioquímicas o fisiológicas

BV02 is an inhibitor of the 14-3-3 scaffolding proteins docking site. BV02 promotes the apoptotic death of cells expressing either wt Bcr-Abl construct or T315I mutation. It induces apoptosis by c-Abl release from 14-3-3? and re-location to nuclear compartment and at mitochondrial membranes.

Información de seguridad

• Pictogramas: GHS09
• Palabra de señalización: Warning
• Frases de peligro: H400
• Consejos de prudencia: P273 - P391 - P501
• Clasificaciones de peligro: Aquatic Acute 1
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable