SML1466

ABH hydrochloride

≥98% (HPLC)

• Sinónimos: 2(S)-Amino-6-boronohexanoic acid hydrochloride, 6-Borono-L-norleucine hydrochloride
• Fórmula empírica (notación de Hill): C₆H₁₄BNO₄ · HCl
• Número de CAS: 194656-75-2
• Peso molecular: 211.45
• Número MDL: MFCD22887376
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329825900
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥98% (HPLC)
• formulario: powder
• actividad óptica: [α]/D +8 to +13°, c = 0.7 in H₂O
• condiciones de almacenamiento: desiccated
• color: white to beige
• solubilidad: H₂O: 20 mg/mL, clear
• temp. de almacenamiento: 2-8°C
• cadena SMILES: OB(O)CCCC[C@H](N)C(O)=O.[H]Cl
• InChI: 1S/C6H14BNO4.ClH/c8-5(6(9)10)3-1-2-4-7(11)12;/h5,11-12H,1-4,8H2,(H,9,10);1H/t5-;/m0./s1
• Clave InChI: XCUVEZUCSHVMRK-JEDNCBNOSA-N

Descripción

Acciones bioquímicas o fisiológicas

ABH (2(S)-amino-6-boronohexanoic acid) is a highly potent and specific arginase inhibitor that inhibits the LPS-induced increases in pulmonary IL-8, neutrophils and goblet cells as well as airway fibrosis in rodent model of COPD.

Selective inhibition of arginase by ABH in animal models is known to ameliorate the effect of diabetes mellitus type 1, autoimmune encephalitis, chronic asthma and vascular stiffness due to aging. ABH inhibition of arginase restores erectile hemodynamics in aging mouse. Ex vivo studies prove that ABH promotes smooth muscle relaxation stimulated by nitric oxide.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable