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Merck
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Key Documents

SRP0375

Sigma-Aldrich

LOXL2 human

recombinant, expressed in FreeStyle™ 293-F cells, ≥86% (SDS-PAGE)

Sinónimos:

LOR2, WS9-14, lysyl oxidase-like 2

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About This Item

Código UNSPSC:
12352202
NACRES:
NA.32

origen biológico

human

recombinante

expressed in FreeStyle™ 293-F cells

Análisis

≥86% (SDS-PAGE)

formulario

aqueous solution

mol peso

85 kDa

envase

pkg of 10 μg

condiciones de almacenamiento

avoid repeated freeze/thaw cycles

concentración

0.23 mg/mL

Nº de acceso NCBI

NM_002318

Nº de acceso UniProt

Q9Y4K0

Condiciones de envío

dry ice

temp. de almacenamiento

−70°C

Información sobre el gen

human ... LOXL2(4017)

Descripción general

Human LOXL2 (GenBank Accession No. NM_002318), amino acids 26 – 774 (end) with C-terminal His tag, MW = 85 kDa, expressed in FreeStyle 293-F cells.
Lysyl oxidase like 2 (LOXL2) is part of the LOX family of proteins. It is widely expressed. The gene encoding this protein is localized on human chromosome 8p21.3. It has a conserved carboxy-terminal region with a catalytic function and a divergent amino-terminal region.

Acciones bioquímicas o fisiológicas

Lysyl oxidase like 2 (LOXL2) is an amino oxidase. LOXL2 is involved in various cellular events such as gene transcription, cell migration, adhesion and differentiation. The protein has a role in connecting collagen and/or elastin in the extracellular matrix. It deaminates trimethylated lysine 4 in histone H3, causing transcriptional repression. LOXL2 suppresses some TFIID (transcription factor IID)-associated genes by oxidising methylated TAF10 (TATA-box binding protein associated factor 10). The LOXL2 gene is upregulated in various cancers, such as gastric cancer, breast cancer and squamous cell carcinomas. The gene is associated with cancer cell invasion and lymph node metastasis.

Forma física

Formulated in 8 mM PBS, pH 7.4, 110 mM NaCl, 2.2 mM KCl, 200 mM imidazole, and 20% glycerol.

Información legal

FreeStyle is a trademark of Invitrogen Corp.

Pictogramas

Health hazardExclamation mark
GHS08,GHS07

Palabra de señalización

Danger

Frases de peligro

H315,H319,H360D

Clasificaciones de peligro

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2

Código de clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Clase de riesgo para el agua (WGK)

WGK 1

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Tumor-suppressive microRNA-29 family inhibits cancer cell migration and invasion directly targeting LOXL2 in lung squamous cell carcinoma
Keiko Mizuno
International Journal of Oncology, 48(2), 450-460 (2016)
Tumour-suppressive microRNA-29s directly regulate LOXL2 expression and inhibit cancer cell migration and invasion in renal cell carcinoma.
Nishikawa R
Febs Letters, 589(16), 2136-2145 (2015)
Debika Mitra et al.
Biotechnology journal, 14(3), e1700763-e1700763 (2018-07-28)
Lysyl oxidase (LOX)-mediated collagen crosslinking can regulate osteoblastic phenotype and enhance mechanical properties of tissues, both areas of interest in bone tissue engineering. The objective of this study is to investigate the effect of lysyl oxidase-like 2 (LOXL2) on osteogenic
Verena Aumiller et al.
Scientific reports, 7(1), 149-149 (2017-03-10)
Extracellular matrix (ECM) composition and stiffness are major driving forces for the development and persistence of fibrotic diseases. Lysyl oxidase (LOX) and LOX-like (LOXL) proteins play crucial roles in ECM remodeling due to their collagen crosslinking and intracellular functions. Here
The function and mechanisms of action of LOXL2 in cancer (Review)
Linghong Wu and Ying Zhu
International Journal of Molecular Medicine, 1200-1204 (2015)
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