SAE0159

Microbial Transglutaminase

lyophilized powder, ≥12 units/mg protein

• Sinónimos: Microbial Enzyme, Transglutaminase, Transglutaminase Enzyme
• Código UNSPSC: 12352204
• NACRES: NA.54

Propiedades

• Formulario: lyophilized powder
• Nivel de calidad: 200
• actividad específica: ≥12 units/mg protein
• Condiciones de envío: dry ice
• temp. de almacenamiento: −20°C

Descripción

Descripción general

Transglutaminases (TG) are a family of enzymes that catalyze isopeptide bond formation. This bond formation occurs between the γ-carboxyamide group of glutamine and various primary amines (primarily the ε-amino group of lysine). The resulting intermolecular or intramolecular cross-linking of transglutaminase is highly stable and shows high resistance to proteolytic degradation. The transglutaminase crosslinking activity support the formation of blood clots , skin and hair. On the other hand, TG is now being implicated in Celiac disease as well as in Huntington and Parkinson diseases. Historically, Microbial transglutaminase has been heavily used in the food industry. Microbial TG is often preferred for newer applications (such as site-specific protein modification and antibody drug conjugation) due to its small molecular weight and lack of calcium dependency when compared to the mammalian forms.

Aplicación

Microbial Transglutaminase has been used for:

• Protein cross-linking & site-specific labeling
• Antibody Drug Conjugation
• 3D bioprinting bioink preparation
• Food related immunogenicity/pathogenicity related research

Características y beneficios

• Small (~38kDa) and calcium independent enzyme
• Highly purified lyophilized enzyme
• Consistent and reproducible activity
• Characterized for endotoxin content

Nota de preparación

For R&D use only. Not for drug, household, or other uses. Please consult the Safety Data Sheet for information regarding hazards and safe handling practices

Almacenamiento y estabilidad

Store the freeze-dried product at –20 °C. It is recommended to store the reconstituted protein in working aliquots at –20 °C to avoid repeated freeze/ thaw cycles.

Información de seguridad

• Pictogramas: GHS08
• Palabra de señalización: Danger
• Frases de peligro: H334
• Consejos de prudencia: P261 - P284 - P304 + P340 + P312 - P501
• Clasificaciones de peligro: Resp. Sens. 1
• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable