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Merck
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Key Documents

SML0956

Sigma-Aldrich

Dexmedetomidine hydrochloride

≥98% (HPLC)

Sinónimos:

(+)-Medetomidine hydrochloride, (S)-Medetomidine hydrochloride, 4-[(S)-α,2,3-Trimethylbenzyl]imidazole monohydrochloride, 5-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride

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About This Item

Fórmula empírica (notación de Hill):
C13H16N2 · HCl
Número de CAS:
145108-58-3
Peso molecular:
236.74
Código UNSPSC:
12352200
NACRES:
NA.77

Nivel de calidad

100

Análisis

≥98% (HPLC)

formulario

powder

actividad óptica

[α]/D +48 to +58°, c = 1 in H2O

condiciones de almacenamiento

desiccated

color

white to beige

solubilidad

H2O: 20 mg/mL, clear

temp. de almacenamiento

2-8°C

InChI

1S/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H/t11-;/m0./s1

Clave InChI

VPNGEIHDPSLNMU-MERQFXBCSA-N

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Aplicación

Dexmedetomidine hydrochloride has been used to study its effects on primary neonatal rat cardiomyocytes under hypoxic/reoxygenation conditions. It has also been used to study the effects of dexmedetomidine pretreatment on lipopolysaccharide-induced acute lung injury in mice.

Acciones bioquímicas o fisiológicas

Dexmedetomidine hydrochloride is a highly potent and selective α2-adrenergic agonist with analgesic and sedative properties, the (+)-isomer of medetomidine. Dexmedetomidine hydrochloride is used clinically as an anesthetic agent to reduce anxiety and tension and promote relaxation and sedation without causing respiratory depression.

Características y beneficios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Otras notas

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Pictogramas

Exclamation markEnvironment
GHS07,GHS09

Palabra de señalización

Warning

Frases de peligro

H302,H336,H411

Clasificaciones de peligro

Acute Tox. 4 Oral - Aquatic Chronic 2 - STOT SE 3

Órganos de actuación

Central nervous system

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Dexmedetomidine attenuates hypoxia/reoxygenation injury in primary neonatal rat cardiomyocytes
Ke Peng
Experimental and Therapeutic Medicine (2017)
Heedoo Yoo et al.
European journal of clinical pharmacology, 71(10), 1197-1207 (2015-08-04)
Dexmedetomidine is an α2-adrenoceptor agonist used for perioperative and intensive care sedation. This study develops mechanism-based population pharmacokinetic-pharmacodynamic models for the cardiovascular and central nervous system (CNS) effects of intravenously (IV) and intranasally (IN) administered dexmedetomidine in healthy subjects. Single
3-Methyladenine and dexmedetomidine reverse lipopolysaccharide-induced acute lung injury through the inhibition of inflammation and autophagy
Dengfeng Ding
Experimental and Therapeutic Medicine, 15.4 (2018)
Luis I Cortínez et al.
European journal of clinical pharmacology, 71(12), 1501-1508 (2015-09-27)
This study aims to characterize the influence of body weight and composition on the pharmacokinetics of dexmedetomidine. Twenty obese patients and 20 non-obese patients scheduled for elective laparoscopic surgery were given dexmedetomidine infusion schemes. Venous blood samples were taken during
Anna K Shoveller et al.
Journal of feline medicine and surgery, 16(12), 957-965 (2014-03-15)
Body condition scoring (BCS) provides a readily available technique that can be used by both veterinary professionals and owners to assess the body condition of cats, and diagnose overweight or underweight conditions. The objective of this study was to evaluate
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