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M-031

Supelco

Morphine-3-β-D-glucuronide solution

1 mg/mL in methanol with 0.05% NaOH, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (notación de Hill):
C23H27NO9
Número de CAS:
20290-09-9
Peso molecular:
461.46
Número MDL:
MFCD00056773
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329817768
NACRES:
NA.24

grado

certified reference material

formulario

liquid

envase

ampule of 1 mL

fabricante / nombre comercial

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentración

1 mg/mL in methanol with 0.05% NaOH

técnicas

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicaciones

forensics and toxicology

formato

single component solution

temp. de almacenamiento

2-8°C

cadena SMILES

O[C@@H](C=C1)[C@H]2[C@](C1[C@H]3C4)(CCN3C)C5=C4C=CC(O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O6)=C5O2

InChI

1S/C23H27NO9/c1-24-7-6-23-10-3-4-12(25)20(23)32-18-13(5-2-9(14(18)23)8-11(10)24)31-22-17(28)15(26)16(27)19(33-22)21(29)30/h2-5,10-12,15-17,19-20,22,25-28H,6-8H2,1H3,(H,29,30)/t10?,11-,12+,15+,16+,17-,19+,20+,22-,23+/m1/s1

Clave InChI

WAEXKFONHRHFBZ-RURUVCMVSA-N

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Categorías relacionadas

Descripción general

A certified solution standard of Morphine-3-ß-D-glucuronide at a concentration of 1.0 mg/mL for high volumes of sample testing. This certified solution standard is suitable for LCMS or GCMS applications including forensic analysis or urine drug testing.

Aplicación


  • Morphine-3-β-ᴅ-glucuronide (M3G) Solution in Clinical Analysis: The use of M3G glucuronide standard in liquid chromatography-tandem mass spectrometry has been validated for quantifying analgesics and sedatives in human plasma, with applications in intensive care and neurological death determination studies. This underlines the solution′s critical role in pharmacokinetic research of morphine metabolites within pharmaceutical sciences (Jutras et al., 2020).

  • Opioid Metabolite Research with M3G: Analysis of opiate and opiate metabolites, including M3G, in urine after consumption of cold syrups by LC-MS/MS, emphasizes the solution′s importance in biochemical assays of morphine derivatives. This research is integral for monitoring drug abuse and optimizing therapeutic strategies in the pharma and biotech sectors (Yen YT et al., 2020).

  • Electrophoresis-based Determination of M3G: Capillary electrophoresis-mass spectrometry has determined morphine and its isobaric glucuronide metabolites, including M3G, as an essential biochemistry tool for studying opioid metabolism. Such methods enable accurate profiling of drug metabolism, serving both research and clinical diagnostic purposes (Isbell TA et al., 2015).

  • M3G Metabolism and UGT2B7 Enzyme: The catalysis of M3G glucuronidation and glucosidation by UDP-glucuronosyltransferase 2B7 highlights the solution′s use in uncovering complementary metabolic pathways of morphine. The findings have significant implications for the biochemist′s understanding of drug metabolism pathways in pharmaceutical research (Chau N et al., 2014).

  • Stability Assessment in Sewage Epidemiology: The stability of drug biomarkers, including M3G in municipal wastewater, influences the estimation of drug consumption. Using high-purity M3G solution as a research standard aids in sewage epidemiology and environmental monitoring (Senta I et al., 2014).


Información legal

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Producto relacionado

Referencia del producto
Descripción
Precios

D-033

Dihydromorphine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

E-052

Ethylmorphine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

IMPM-005-05

10-Hydroxymorphine solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

IMPM-005-06

10-Oxomorphine solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-003

Morphine-D3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-005

Morphine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-006

Morphine-D3 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-017

Morphine-D3-3-β-D-glucuronide solution, 100 μg/mL in methanol with 0.05% NaOH, ampule of 1 mL, certified reference material, Cerilliant®

M-018

Morphine-3-β-D-glucuronide solution, 100 μg/mL in methanol: water ( 50:50(v/v)), ampule of 1 mL, certified reference material, Cerilliant®

M-030

Morphine solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-046

Morphine-6-β-D-glucuronide solution, 1.0 mg/mL in methanol: water (2:8), ampule of 1 mL, certified reference material, Cerilliant®

M-085

Morphine-D6 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-086

Morphine-D6 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-096

Morphine-6-β-D-glucuronide solution, 100 μg/mL in methanol: water (1:1), ampule of 1 mL, certified reference material, Cerilliant®

M-120

Morphine-6-β-D-glucuronide-D3 solution, 100 μg/mL in methanol: water (1:1), ampule of 1 mL, certified reference material, Cerilliant®

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Órganos de actuación

Eyes,Central nervous system

Código de clase de almacenamiento

3 - Flammable liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

51.8 °F - closed cup

Punto de inflamabilidad (°C)

11 °C - closed cup

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Visite la Librería de documentos

Shawn McCann et al.
Journal of opioid management, 6(2), 87-94 (2010-05-21)
The 3-glucuronide metabolites of morphine and hydromorphone have been implicated as a causative factor for patients exhibiting myoclonus. The primary goal of this study was to determine plasma levels of morphine-3-glucuronide (M3G) or hydromorphone-3-glucuronide (H3G) in patients demonstrating myoclonus and
Yoshitaka Hasegawa et al.
The Journal of pharmacy and pharmacology, 62(3), 310-314 (2010-05-22)
The aim was to investigate the pharmacokinetics of morphine and its metabolite, morphine-3-glucuronide (M3G), in a rat model of streptozotocin (STZ)-induced diabetes. Morphine (15 mg/kg) was administered intravenously, and the concentrations of morphine and M3G in the plasma, urine and
Arief Nurrochmad et al.
Drug metabolism and pharmacokinetics, 25(3), 262-273 (2010-07-09)
The formation of morphine-3-glucuronide (M-3-G, pharmacologically inactive) and morphine-6-glucuronide (M-6-G, active metabolite) by liver microsomes from humans and rodents, including chimeric mice carrying human liver, was evaluated in the presence of fatty acyl-CoAs. Medium- to long-chain fatty acyl-CoAs, including oleoyl-CoAs
Maarten Swartjes et al.
Molecular medicine (Cambridge, Mass.), 18, 1320-1326 (2012-09-25)
Opioid-induced hyperalgesia (OIH) is a paradoxical increase in pain perception that may manifest during opioid treatment. For morphine, the metabolite morphine-3-glucuronide (M3G) is commonly believed to underlie this phenomenon. Here, in three separate studies, we empirically assess the role of
Michael R Due et al.
Journal of neuroinflammation, 9, 200-200 (2012-08-18)
Multiple adverse events are associated with the use of morphine for the treatment of chronic non-cancer pain, including opioid-induced hyperalgesia (OIH). Mechanisms of OIH are independent of opioid tolerance and may involve the morphine metabolite morphine-3-glucuronide (M3G). M3G exhibits limited
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Protocolos

Using UHPLC/MS (TOF) for Detection of Drugs and Metabolites in Urine Following Optimized Enzymatic Hydrolysis Conditions

To optimize hydrolysis using β-glucuronidase, factors such as incubation time, temperature, hydrolysis pH, enzyme source, and enzyme concentration must be evaluated for each glucuronide metabolite to be analyzed.

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