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M-046

Supelco

Morphine-6-β-D-glucuronide solution

1.0 mg/mL in methanol: water (2:8), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (notación de Hill):
C23H27NO9
Número de CAS:
20290-10-2
Peso molecular:
461.46
Número MDL:
MFCD00079434
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329817792
NACRES:
NA.24

grado

certified reference material

Nivel de calidad

300

formulario

liquid

Características

Snap-N-Spike®/Snap-N-Shoot®

envase

ampule of 1 mL

fabricante / nombre comercial

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

concentración

1.0 mg/mL in methanol: water (2:8)

técnicas

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicaciones

forensics and toxicology

formato

single component solution

temp. de almacenamiento

−20°C

cadena SMILES

CN1CC[C@]23[C@H]4Oc5c(O)ccc(C[C@@H]1[C@@H]2C=C[C@@H]4O[C@@H]6O[C@@H]([C@@H](O)[C@H](O)[C@H]6O)C(O)=O)c35

InChI

1S/C23H27NO9/c1-24-7-6-23-10-3-5-13(31-22-17(28)15(26)16(27)19(33-22)21(29)30)20(23)32-18-12(25)4-2-9(14(18)23)8-11(10)24/h2-5,10-11,13,15-17,19-20,22,25-28H,6-8H2,1H3,(H,29,30)/t10-,11+,13-,15-,16-,17+,19-,20-,22+,23-/m0/s1

Clave InChI

GNJCUHZOSOYIEC-GAROZEBRSA-N

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Descripción general

A certified solution standard of Morphine-6-β-D-glucuronide at a concentration of 1.0 mg/mL for high volumes of sample testing. This new certified solution standard is suitable for LCMS or GCMS applications including forensic analysis or urine drug testing.

Aplicación



  • High-efficacy opioid receptor agonist: Research identifies Morphine-6-β-ᴅ-glucuronide as having higher efficacy compared to morphine when acting as a mu-opioid receptor agonist in rat models, highlighting its potential for enhanced opioid research and applications in pain management (Osborne et al., 2000).


  • Application in clinical pharmacokinetics: A study developed and validated a liquid chromatography-mass spectrometry method for the simultaneous quantification of various analgesics and sedatives, including Morphine-6-β-ᴅ-glucuronide, aiding in clinical pharmacokinetic studies and potentially improving drug monitoring and safety in intensive care settings (Jutras et al., 2020).


Información legal

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

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Morphine-3-β-D-glucuronide solution, 1 mg/mL in methanol with 0.05% NaOH, ampule of 1 mL, certified reference material, Cerilliant®

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M-005

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M-017

Morphine-D3-3-β-D-glucuronide solution, 100 μg/mL in methanol with 0.05% NaOH, ampule of 1 mL, certified reference material, Cerilliant®

M-018

Morphine-3-β-D-glucuronide solution, 100 μg/mL in methanol: water ( 50:50(v/v)), ampule of 1 mL, certified reference material, Cerilliant®

M-030

Morphine solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-085

Morphine-D6 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-086

Morphine-D6 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-096

Morphine-6-β-D-glucuronide solution, 100 μg/mL in methanol: water (1:1), ampule of 1 mL, certified reference material, Cerilliant®

M-120

Morphine-6-β-D-glucuronide-D3 solution, 100 μg/mL in methanol: water (1:1), ampule of 1 mL, certified reference material, Cerilliant®

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Flam. Liq. 3 - STOT SE 1

Órganos de actuación

Eyes

Código de clase de almacenamiento

3 - Flammable liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

109.4 °F - closed cup

Punto de inflamabilidad (°C)

43 °C - closed cup

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Claire Trécant et al.
European journal of medicinal chemistry, 46(9), 4035-4041 (2011-06-22)
Synthesis and biological evaluation of new derivatives of Morphine-6-Glucuronide (M6G) are described. M6G is an active metabolite of morphine which displays more analgesia than morphine with a superior side effect profile but with a less efficiently BBB penetration. These phenomena
J A Hannam et al.
Anaesthesia and intensive care, 40(5), 867-870 (2012-09-01)
A morphine plasma concentration/respiratory rate relationship has been described for both adults and children although that of its metabolite, morphine-6-glucuronide, remains uncertain. We describe this relationship in a child with end-stage renal failure who received repeat morphine administration over two
Kristin Moksnes et al.
European journal of clinical pharmacology, 68(8), 1147-1156 (2012-03-01)
Our aim was to compare pharmacological aspects of two switching strategies from morphine/oxycodone to methadone; the stop and go (SAG) strategy in which methadone is started directly after the initial opioid has been stopped, and the 3-days switch (3DS), in
Alexander T Nguyen et al.
European journal of pharmacology, 682(1-3), 86-91 (2012-03-01)
Previous studies have shown that morphine-6-glucuronide (M6G), a metabolite of morphine, induces reward and psychomotor stimulation but the role of the mu opioid receptor in these actions of the drug is not fully characterized. Thus, using mice lacking exon-2 of
Claudia F Clavijo et al.
Analytical and bioanalytical chemistry, 400(3), 715-728 (2011-03-15)
Opioids such as morphine are the cornerstone of pain treatment. The challenge of measuring the concentrations of morphine and its active metabolites in order to assess human pharmacokinetics and monitor therapeutic drugs in children requires assays with high sensitivity in
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