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SML0320

Sigma-Aldrich

FR180204

≥98% (HPLC)

Sinónimos:

5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine, 5-(2-Phenylpyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-amine, FR 180204

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About This Item

Fórmula empírica (notación de Hill):
C18H13N7
Número de CAS:
865362-74-9
Peso molecular:
327.34
Número MDL:
MFCD14585805
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329825325
NACRES:
NA.77

Análisis

≥98% (HPLC)

formulario

powder

color

faintly yellow to dark yellow

solubilidad

DMSO: ≥10 mg/mL

temp. de almacenamiento

2-8°C

cadena SMILES

Nc1n[nH]c2nnc(cc12)-c3c(nn4ccccc34)-c5ccccc5

InChI

1S/C18H13N7/c19-17-12-10-13(20-22-18(12)23-21-17)15-14-8-4-5-9-25(14)24-16(15)11-6-2-1-3-7-11/h1-10H,(H3,19,21,22,23)

Clave InChI

XVECMUKVOMUNLE-UHFFFAOYSA-N

Aplicación

FR180204 has been used as ERK inhibitor:
  • to block extracellular-signal-regulated kinase (ERK) in order to validate whether homeobox B7 (HOXB7) regulates the migration and proliferation process via AKT/mitogen-activated protein kinases (MAPK) signaling
  • of extracellular-signal-regulated kinase (ERK) to study the effects of signaling pathway inhibitors on differentiation and cell traction stress
  • to determine if phosphorylation of this signaling protein is essential for mesenchymal stromal cell (MSC) derived therapeutic efficacy

Acciones bioquímicas o fisiológicas

FR180204 is a potent, cell-permeable, ATP-competitive inhibitor of ERK1 and ERK2 (mitogen-activated protein kinase (MAPK)/extracellular-signal-regulated kinases (ERK) 1/2).
It can be used to study the roles of ERK as well as for drug development.

Características y beneficios

This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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U0126 U0126 is a elective inhibitor of MEK-1 and MEK-2; weak inhibitor of PKC, Raf, ERK, JNK, MEKK, MKK-3, MKK-4/SEK, MKK-6, Abl, Cdk2 and Cdk4.

Sigma-Aldrich

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Sigma-Aldrich

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Sigma-Aldrich

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Substrate stiffness and matrix composition coordinately control the differentiation of liver progenitor cells
Kourouklis AP, et al.
Biomaterials, 99, 82-94 (2016)
HOXB7 overexpression promotes cell proliferation and correlates with poor prognosis in gastric cancer patients by inducing expression of both AKT and MARKs
He X, et al.
Oncotarget, 8(1), 1247-1247 (2017)
Yuki Shindo et al.
Nature communications, 7, 10485-10485 (2016-01-21)
The phosphorylation cascade in the extracellular signal-regulated kinase (ERK) pathway is a versatile reaction network motif that can potentially act as a switch, oscillator or memory. Nevertheless, there is accumulating evidence that the phosphorylation response is mostly linear to extracellular
Mario Sechi et al.
Scientific reports, 8(1), 15726-15726 (2018-10-26)
The anti-proliferative activity of dietary flavonoid fisetin has been validated in various cancer models. Establishing its precise mechanism of action has proved somewhat challenging given the multiplicity of its targets. We demonstrated that YB-1 promotes epithelial-to-mesenchymal transition and its inhibition
Maren Bakkebø et al.
BMC immunology, 11, 57-57 (2010-11-26)
Cytokines of the transforming growth factor β (TGF-β) superfamily exert effects on proliferation, apoptosis and differentiation in various cell types. Cancer cells frequently acquire resistance to the anti-proliferative signals of TGF-β, which can be due to mutations in proteins of
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Artículos

MAPKs

The mitogen-activated protein kinase (MAPK) family consists of both stress activated (SAPK) and mitogen-activated (MAPK) protein kinases. They form a network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli, including growth factors, chemical or osmotic stress, irradiation, bacterial infection and proinflammatory cytokines.

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