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SML0054

Sigma-Aldrich

Schizandrin

≥98% (HPLC)

Sinónimos:

(+)-Schizandrin, Schisandrin, Schisandrine, Wuweizi alcohol A, Wuweizichun A

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About This Item

Fórmula empírica (notación de Hill):
C24H32O7
Número de CAS:
7432-28-2
Peso molecular:
432.51
Número MDL:
MFCD00905761
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
329825121
NACRES:
NA.77

Nivel de calidad

100

Ensayo

≥98% (HPLC)

Formulario

powder

actividad óptica

[α]/D 75 to 95°, c = 1 in methanol

color

white to beige

solubilidad

DMSO: ≥13 mg/mL

temp. de almacenamiento

room temp

cadena SMILES

COc1cc2C[C@H](C)[C@@](C)(O)Cc3cc(OC)c(OC)c(OC)c3-c2c(OC)c1OC

InChI

1S/C24H32O7/c1-13-9-14-10-16(26-3)20(28-5)22(30-7)18(14)19-15(12-24(13,2)25)11-17(27-4)21(29-6)23(19)31-8/h10-11,13,25H,9,12H2,1-8H3/t13-,24-/m0/s1

Clave InChI

YEFOAORQXAOVJQ-RZFZLAGVSA-N

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Aplicación

Schizandrin may be used in oxidative stress-related cell signaling studies.

Acciones bioquímicas o fisiológicas

Schizandrin is a natural product with several biological properties involved with antioxidant and anti-inflammatory activities. It reduces the formation of ROS, inhibits the mitochondrial pathway of the apoptotic process and oxidative stress. Schizandrin has been reported to have hepatoprotective, antitumor, antiviral, and antiamnesic effects, and has neuroprotective activity against glutamate induced neurotoxicity.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number
116M4754V
076M4717V
095M4717V
074M4714V
113M4710V

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Ju-Xian Song et al.
Phytotherapy research : PTR, 25(3), 435-443 (2010-08-27)
Aggregated beta-amyloid (Aβ) and elevated plasma levels of homocysteine have been implicated as critical factors in the pathogenesis of Alzheimer's disease. The neuroprotective effects and possible mechanism of four structurally similar dibenzocyclooctadiene lignans (namely schisandrin, schisantherin A, schisandrin B and
Di Hu et al.
Oxidative medicine and cellular longevity, 2012, 721721-721721 (2012-07-26)
In the present study, we examined the effect of schisandrin (SCH) of Schisandra chinensis on the amyloid-beta(1-42)- (Aβ(1-42)-) induced memory impairment in mice and elucidated the possible antioxidative mechanism. Mice were intracerebroventricular (i.c.v.) injected with the aggregated Aβ(1-42) and then
Meng-Shiou Lee et al.
Molecules (Basel, Switzerland), 18(1), 354-372 (2012-12-29)
Glutamate-induced excitotoxicity has been implicated in a variety of neuronal degenerative disorders. In the present study, we investigated the possible neuroprotective effects of schizandrin against apoptosis of primary cultured rat cortical cells induced by glutamate. Glutamate (10 μM) administered for
Fan-Yu Meng et al.
Organic letters, 13(6), 1502-1505 (2011-02-23)
Schiglautone A (1), a unique 6/7/9-fused tricyclic carbon backbone triterpenoid, was isolated from the stems of Schisandra glaucescens. Its structure was determined on the basis of spectroscopic analysis and single-crystal X-ray crystallography. A hypothetical biosynthetic pathway of 1 was postulated.
Seung-Il Jeong et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(3-4), 1045-1053 (2011-12-06)
High glucose (HG) is the underlying factor contributing to long term complication of diabetes mellitus. Reactive oxygen species (ROS) have been postulated as a unifying mechanism for HG-induced complications. NADPH oxidase, producing superoxide anion, is the main source of ROS
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