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SML0786

Sigma-Aldrich

Decursin

≥97% (HPLC)

Sinónimos:

(+)-Decursin, (7S)-7,8-Dihydro-8,8-dimethyl-2-oxo-2H,6H-benzo[1,2-b:5,4-b′]dipyran-7-yl 3-methyl-2-butenoate, 3-Methyl-2-butenoic acid (7S)-7,8-dihydro-8,8-dimethyl-2-oxo-2H,6H-pyrano[3,2-g]-1-benzopyran-7-yl ester

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About This Item

Fórmula empírica (notación de Hill):
C19H20O5
Número de CAS:
5928-25-6
Peso molecular:
328.36
Número MDL:
MFCD00272154
Código UNSPSC:
12352200
NACRES:
NA.77

origen biológico

Radix peucedani

Nivel de calidad

100

Análisis

≥97% (HPLC)

formulario

powder

actividad óptica

[α]/D +120 to +160°, c = 0.5 in chloroform-d

color

white to beige

solubilidad

DMSO: 5 mg/mL, clear

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

InChI

1S/C19H20O5/c1-11(2)7-18(21)23-16-9-13-8-12-5-6-17(20)22-14(12)10-15(13)24-19(16,3)4/h5-8,10,16H,9H2,1-4H3/t16-/m0/s1

Clave InChI

CUKSFECWKQBVED-INIZCTEOSA-N

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Acciones bioquímicas o fisiológicas

Decursin is a cumarin isolated from Radix peucedani that exhibits a number of physiological actions including anticancer, antibacterial, antinematodal and antioxidant. Decursin is potent anti-angiogenic agent targeting the VEGFR-2 signaling pathway. Decursin exhibits potent neuroprotective activity against glutamate and Ab- induced neurotoxicity. Apparently, decursin stimulates activation of Nerf2. Also, decursin inhibits androgen stimulated AR translocation to the nucleus in LNCaP prostate cancer cells.

Características y beneficios

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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Jin-Taek Hwang et al.
Phytotherapy research : PTR, 26(5), 633-638 (2011-10-06)
Decursin (De), an active component of Angelica gigas, is known to exert anticancer and neuroprotective effects. However, its antiobesity and antidiabetic potential has not yet been investigated. This study evaluated the antiobesity effect of decursin, particularly focusing on its ability
Tariq A Bhat et al.
Indian journal of experimental biology, 49(11), 848-856 (2011-12-01)
The present study was undertaken to observe the inhibition of angiogenesis by decursin. It was the first time to show that decursin offered strong anti-angiogenic activities under the biologically relevant growth (with serum) conditions. Decursin significantly inhibited human umbilical vein
Seung Hwa Son et al.
Phytotherapy research : PTR, 25(7), 959-964 (2010-12-21)
The principal objective of the present study was to evaluate the antimetastatic activity of decursin and decursinol isolated from Angelica gigas. Decursin and decursinol inhibited the proliferation and invasion of CT-26 colon carcinoma cells. The expressions of matrix metalloproteinase (MMP)-2
Bimit Mahat et al.
Drug development and industrial pharmacy, 39(10), 1523-1530 (2012-09-26)
Angelica gigas Nakai and its components are known to have neuroprotective, antiplatelet, and anticancer activities. The present study evaluated the in vitro and in vivo biopharmaceutical characterization of Angelica gigas component substances, including decursin (the main substance), decursinol angelate (decursin
Jung-woo Chae et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(10), 3666-3672 (2012-07-10)
Herb-drug interactions represent a serious problem as herbal medicine is used extensively in the modern world. This study investigated the effects of decursinol angelate on the pharmacokinetics of theophylline, a typical substrate of the cytochrome P450 1A2 enzyme, in rats.
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