M3949

MST-312

≥98% (HPLC)

• Sinónimos: N,N′-1,3-Phenylenebis-[2,3-dihydroxy-benzamide]
• Fórmula empírica (notación de Hill): C₂₀H₁₆N₂O₆
• Número de CAS: 368449-04-1
• Peso molecular: 380.35
• Número MDL: MFCD24368986
• Código UNSPSC: 12352200
• ID de la sustancia en PubChem: 329817985
• NACRES: NA.77

Propiedades

• Nivel de calidad: 100
• Análisis: ≥98% (HPLC)
• formulario: powder
• color: off-white to light tan
• solubilidad: DMSO: ≥20 mg/mL
• temp. de almacenamiento: 2-8°C
• cadena SMILES: Oc1cccc(C(=O)Nc2cccc(NC(=O)c3cccc(O)c3O)c2)c1O
• InChI: 1S/C20H16N2O6/c23-15-8-2-6-13(17(15)25)19(27)21-11-4-1-5-12(10-11)22-20(28)14-7-3-9-16(24)18(14)26/h1-10,23-26H,(H,21,27)(H,22,28)
• Clave InChI: MIQUEZGHEJGPJB-UHFFFAOYSA-N

Descripción

Aplicación

MST-312 has been used in cell invasion assay using mouse fibroblast cells (NIH-3T3) and in the co-immunoprecipitation experiments in colon fibroblast.

Acciones bioquímicas o fisiológicas

MST-312 is a telomerase Inhibitor. Telomeres are nucleoprotein complexes present on the ends of chromosomes, containing DNA segment tandem repeats that shorten with each repetitive cell cycle. Telomere shortening leads to loss of function, resulting in cell senescence and limited survivability. The reverse transcriptase, telomerase, maintains telomere length and function in immortalized cell lines and most cancer cell lines, and telomerase activity is associated with tumorigenesis. Telomere elongation is also believed to be an important contributor to the genomic stability and indefinite self renewal of iPS cells. 1 μM MST-312 was shown to effectively reduce telomere length and inhibit proliferation in U937 cells.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 2
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable