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Key Documents

SAB4502493

Sigma-Aldrich

Anti-PTHR1 antibody produced in rabbit

affinity isolated antibody

Sinónimos:

PTH1 Receptor, PTH1R, PTHR, Parathyroid hormone 1 receptor

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About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.41

origen biológico

rabbit

Nivel de calidad

conjugado

unconjugated

forma del anticuerpo

affinity isolated antibody

tipo de anticuerpo

primary antibodies

clon

polyclonal

formulario

buffered aqueous solution

mol peso

antigen 52 kDa

reactividad de especies

rat, mouse, human

concentración

~1 mg/mL

técnicas

ELISA: 1:10000
immunofluorescence: 1:100-1:500
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

Nº de acceso NCBI

Nº de acceso UniProt

Condiciones de envío

wet ice

temp. de almacenamiento

−20°C

modificación del objetivo postraduccional

unmodified

Información sobre el gen

human ... PTH1R(5745)

Descripción general

Anti-PTHR1 antibody detects endogenous levels of total PTHR1 protein.
PTHR1 (parathyroid hormone 1 receptor) gene is mapped to human chromosome 3p21.31. The gene encodes for a precursor (secretin-like class II G protein-coupled receptor) that matures to a receptor containing 593 amino acids. This receptor contains an extracellular loop with a PTH binding site and an intracellular signaling domain. It also includes seven transmembrane and helical segments. The gene is predominantly expressed in osteoblasts and renal tubular cells.

Inmunógeno

The antiserum was produced against synthesized peptide derived from human PTHR1.

Immunogen Range: 145-194

Acciones bioquímicas o fisiológicas

Heterozygous mutation of PTHR1 (parathyroid hormone 1 receptor) gene is known to cause primary failure of tooth eruption in human, with partial eruption of posterior teeth and reduced alveolar growth process. PTHR1 is associated with bone remodeling (bone formation and resorption, anabolic and catabolic responses respectively) and calcium homeostasis. Blomstrand chondrodysplasia results due to complete loss of PTHR1 function, and is considered lethal.

Características y beneficios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Forma física

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de clase de almacenamiento

10 - Combustible liquids

Clase de riesgo para el agua (WGK)

nwg

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable


Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

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A novel homozygous PTH1R variant identified through whole-exome sequencing further expands the clinical spectrum of primary failure of tooth eruption in a consanguineous Saudi family.
Jelani M.
Archives of Oral Biology, 67, 28-33 (2016)
Katja Braun et al.
Physiological reports, 6(17), e13842-e13842 (2018-09-11)
An active lifestyle is generally recommended for hypertensive patients to prevent subsequent end-organ damage. However, experimental data on long-term effects of exercise on hypertension are insufficient and underlying mechanisms are not well understood. This study was aimed to investigate the
VMP1 Establishes ER-Microdomains that Regulate Membrane Contact Sites and Autophagy.
Tabara LC and Escalante R
PLoS ONE, 11(11), 1-20 (2016)
Lei Xiong et al.
EBioMedicine, 9, 45-60 (2016-06-23)
Parathyroid hormone (PTH) plays critical, but distinct, roles in bone remodeling, including bone formation (anabolic response) and resorption (catabolic response). Although its signaling and function have been extensively investigated, it just began to be understood how distinct functions are induced
Samantha R Weaver et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 36(5), 986-999 (2021-01-13)
Endochondral ossification is tightly controlled by a coordinated network of signaling cascades including parathyroid hormone (PTH). Pleckstrin homology (PH) domain and leucine rich repeat phosphatase 1 (Phlpp1) affects endochondral ossification by suppressing chondrocyte proliferation in the growth plate, longitudinal bone

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