SAE0192
Parathyroid Hormone (1-84) Human
Recombinant expressed in E. coli
Sinónimos:
PTH, Parathormone
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About This Item
Código UNSPSC:
12352200
NACRES:
NA.77
recombinante
expressed in E. coli
Nivel de calidad
Análisis
≥95% (SDS-PAGE)
Condiciones de envío
ambient
temp. de almacenamiento
−20°C
Descripción general
Parathyroid hormone (PTH), or parathormone, is secreted by the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calcium in the blood, whereas calcitonin (a hormone produced by the parafollicular cells of the thyroid gland) acts to decrease calcium concentration.
Parathyroid Hormone 1-84 (full length) Human Recombinant produced in E. coli is a single, non-glycosylated, polypeptide chain containing 84 amino acids (MW of ∼9.4kDa) with the following amino acid sequence:
SVSEIQLMHN LGKHLNSMER VEWLRKKLQD VHNFVALGAP LAPRDAGSQR PRKKEDNVLV ESHEKSLGEA DKADVNVLTK AKSQ
Parathyroid Hormone 1-84 (full length) Human Recombinant produced in E. coli is a single, non-glycosylated, polypeptide chain containing 84 amino acids (MW of ∼9.4kDa) with the following amino acid sequence:
SVSEIQLMHN LGKHLNSMER VEWLRKKLQD VHNFVALGAP LAPRDAGSQR PRKKEDNVLV ESHEKSLGEA DKADVNVLTK AKSQ
Acciones bioquímicas o fisiológicas
PTH acts to increase the concentration of calcium in the blood by acting upon parathyroid hormone receptor in three parts of the body: In the bones- It enhances the release of calcium from the large reservoir contained in the bones. Bone resorption is the normal destruction of bone by osteoclasts, which are indirectly stimulated by PTH. Recombinant Human full length PTH 1-84 has potential as an anti-osteoporotic agent, due to its properties as a bone formation stimulant, it increases bone turnover, stimulating osteoblasts and reducing both vertebral and non-vertebral fractures.
Forma física
The product is supplied as lyophilized powder, from a 0.2μm filtered concentrated solution in PBS pH7.4.
Almacenamiento y estabilidad
It is recommended to reconstitute the lyophilized PTH in sterile purified water, at not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.
Upon reconstitution PTH should be stored at 2-8 °C up to 7 days and for future use at -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid freeze-thaw cycles
Upon reconstitution PTH should be stored at 2-8 °C up to 7 days and for future use at -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid freeze-thaw cycles
Cláusula de descargo de responsabilidad
This product is for R&D use only, not for drug, household, or other uses. Please consult the Material Safety Data Sheet for information regarding hazards and safe handling practices.
Código de clase de almacenamiento
13 - Non Combustible Solids
Clase de riesgo para el agua (WGK)
WGK 3
Certificados de análisis (COA)
Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»
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