SAB3501285

Anti-PACS1 antibody produced in rabbit

affinity isolated antibody

• Código UNSPSC: 12352203

Propiedades

• origen biológico: rabbit
• Nivel de calidad: 100
• conjugado: unconjugated
• forma del anticuerpo: affinity isolated antibody
• tipo de anticuerpo: primary antibodies
• clon: polyclonal
• formulario: liquid
• reactividad de especies: rat, mouse, human
• concentración: 1 mg/mL
• técnicas: immunofluorescence: suitable; immunohistochemistry: suitable; western blot: suitable
• isotipo: IgG
• Nº de acceso NCBI: NP_060496
• Nº de acceso UniProt: Q6VY07
• Condiciones de envío: wet ice
• temp. de almacenamiento: −20°C
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... PACS1(55690)

Descripción

Descripción general

The phosphofurin acidic cluster sorting protein 1 (PACS1), belongs to the PACS family of cytosolic connector proteins that localize different membrane proteins to the trans-Golgi network (TGN) (1,2). Mutations in PACS1 cause defects in cranial-neural crest migration during early development, leading to a recognizable intellectual disability syndrome. PACS1, along with the related protein PACS2, also plays a role in HIV-1 Nef-mediated downregulation of cell surface MHC-I molecules to the TGN, thereby enabling HIV-1 to escape immune surveillance.

Inmunógeno

PACS1 antibody was raised against a 17 amino acid peptide near the center of human PACS1.The immunogen is located within amino acids 430 - 480 of PACS1.

Aplicación

PACS1 antibody can be used for detection of PACS1 by Western blot at 1 - 2 μg/ml. Antibody can also be used for immunohistochemistry starting at 2 μg/mL For immunofluorescence start at 20 μg/mL. Antibody validated: Western Blot in rat samples; Immunohistochemistry in mouse samples and Immunofluorescence in human and mouse samples. All other applications and species not yet tested.

Forma física

Supplied in PBS containing 0.02% sodium azide.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): nwg
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable