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S6510

Sigma-Aldrich

N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin

≥90% (HPLC)

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About This Item

Fórmula empírica (notación de Hill):
C40H53N5O10
CAS Number:
94367-21-2
Peso molecular:
763.88
Número MDL:
MFCD00080248
Código UNSPSC:
12352200
ID de la sustancia en PubChem:
24899709
NACRES:
NA.77
En este momento no podemos mostrarle ni los precios ni la disponibilidad

Nivel de calidad

200

Ensayo

≥90% (HPLC)

Formulario

powder

solubilidad

0.1% trifluoroacetic acid in acetonitrile: water (3:1): 1 mg/mL, clear, colorless

temp. de almacenamiento

−20°C

cadena SMILES

CC(C)CC(NC(=O)CCC(O)=O)C(=O)NC(CC(C)C)C(=O)NC(C(C)C)C(=O)NC(Cc1ccc(O)cc1)C(=O)Nc2ccc3C(C)=CC(=O)Oc3c2

InChI

1S/C40H53N5O10/c1-21(2)16-29(42-33(47)14-15-34(48)49)38(52)43-30(17-22(3)4)39(53)45-36(23(5)6)40(54)44-31(19-25-8-11-27(46)12-9-25)37(51)41-26-10-13-28-24(7)18-35(50)55-32(28)20-26/h8-13,18,20-23,29-31,36,46H,14-17,19H2,1-7H3,(H,41,51)(H,42,47)(H,43,52)(H,44,54)(H,45,53)(H,48,49)

Clave InChI

UVFAEQZFLBGVRM-UHFFFAOYSA-N

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1 of 4

Este artículo
S8758S4939A8171
N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin ≥90% (HPLC)

S6510

N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin

N-Succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin protease substrate

S8758

N-Succinyl-Ala-Ala-Phe-7-amido-4-methylcoumarin

N-Succinyl-Leu-Leu-Val-Tyr-7-amido-4-trifluoromethylcoumarin ≥98% (HPLC), solid

S4939

N-Succinyl-Leu-Leu-Val-Tyr-7-amido-4-trifluoromethylcoumarin

D-Ala-Leu-Lys-7-amido-4-methylcoumarin ≥95% (HPLC)

A8171

D-Ala-Leu-Lys-7-amido-4-methylcoumarin

form

powder

form

powder

form

solid

form

powder

assay

≥90% (HPLC)

assay

≥98%

assay

≥98% (HPLC)

assay

≥95% (HPLC)

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

0.1% trifluoroacetic acid in acetonitrile: water (3:1): 1 mg/mL, clear, colorless

solubility

50% acetic acid: 1 mg/mL, clear, colorless

solubility

DMF: 1 mg/mL, clear, colorless to light yellow

solubility

water: 1 mg/mL, clear, colorless

Amino Acid Sequence

N-Suc-Leu-Leu-Val-Tyr-7-AMC

Aplicación

N-succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin was used in proteasome chymotrypsin-like activity assay in Jurkat cell lysate6 and crude cell lysate of rice.7

Acciones bioquímicas o fisiológicas

In the presence of chymotrypsin-like enzyme activity, the fluorophore, 7-amido-4-methylcoumarin is released from N-succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin. The fluorescence obtained is a measure of the enzyme activity.6

Envase

Bottomless glass bottle. Contents are inside inserted fused cone.

Sustratos

Fluorogenic substrate for chymotrypsin-like enzymes, such as cathepsin B and calpain which have been implicated in programmed cell death.

Frases de peligro

H413

Consejos de prudencia

P273

Clasificaciones de peligro

Aquatic Chronic 4

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Equipo de protección personal

Eyeshields, Gloves, type N95 (US)

  • Hoja de especificación

    • Elija entre una de las versiones más recientes:

    Certificados de análisis (COA)

    Lot/Batch Number
    BCCF9437
    BCBX5992
    BCBT8774
    BCBF0100V
    BCBQ3198V

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    Proceedings of the National Academy of Sciences of the United States of America, 96(11), 6223-6228 (1999-05-26)
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