RAB1271
Human Arginase 1 ELISA
for serum, plasma and cell culture supernatants
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About This Item
Código UNSPSC:
41116158
NACRES:
NA.32
Productos recomendados
reactividad de especies
human
envase
kit of 96 wells (12 strips x 8 wells)
técnicas
ELISA: suitable
entrada
sample type plasma
sample type serum
sample type cell culture supernatant(s)
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 2.05 ng/mL
standard curve range: 2.048-500 ng/mL
método de detección
colorimetric
Condiciones de envío
wet ice
temp. de almacenamiento
−20°C
Información sobre el gen
human ... ARG1(383)
Descripción general
The gene encoding arginase 1 (ARG1), spanning 10-15kb on genomic DNA, is localized on human chromosome 6q23.2. It consists of eight exons. The protein consists of 322 amino acids and is expressed in the liver, red blood cells, lactating mammalian glands and the kidney.
Aplicación
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
Acciones bioquímicas o fisiológicas
Arginase 1 (ARG1) is a liver enzyme involved in the hydrolysis of arginine to form ornithine and urea. In addition to urea cycle, ARG1 is also implicated in various cellular processes, such as macrophage-mediated cytotoxicity and regulation of immune response. The encoded protein is also involved in allergen challenged lungs, in autoimmune inflammation in the central nervous system and in acute liver injury. Deficiency or mutations in the gene leads to a rare urea cycle disorder, argininemia.
Otras notas
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
Palabra de señalización
Warning
Frases de peligro
Consejos de prudencia
Clasificaciones de peligro
Met. Corr. 1
Código de clase de almacenamiento
8A - Combustible corrosive hazardous materials
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Fernando Holguin et al.
JCI insight, 4(24) (2019-11-13)
BACKGROUNDThe airways of obese asthmatics have been shown to be NO deficient, and this contributes to airway dysfunction and reduced response to inhaled corticosteroids. In cultured airway epithelial cells, L-citrulline, a precursor of L-arginine recycling and NO formation, has been
Clinical phenotype, biochemical profile, and treatment in 19 patients with arginase 1 deficiency
Martina Huemer
Journal of inherited metabolic disease, 39 (2016)
Five Novel Mutations in ARG1 Gene in Chinese Patients of Argininemia
Tong-Fei Wu MD
Pediatric Neurology (2013)
Carbon nanotube-based sensing devices for human Arginase-1 detection
S. Baldo
Sensitization of Cancer Cells for Chemo/Immuno/Radio-therapy, 7 (2016)
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