R1903

RS 102895 hydrochloride

≥98% (HPLC), powder

• Sinónimos: 1′-[2-[4-(Trifluoromethyl)phenyl]ethyl]-spiro[4H-3,1-benzoxazine-4,4′-peperidin]-2(1H)-one
• Fórmula empírica (notación de Hill): C₂₁H₂₁F₃N₂O₂ · HCl
• Peso molecular: 426.86
• Número MDL: MFCD08703093
• Código UNSPSC: 12352202
• ID de la sustancia en PubChem: 24724588
• NACRES: NA.32

Propiedades

• Nivel de calidad: 100
• Ensayo: ≥98% (HPLC)
• Formulario: powder
• mol peso: 426.86 g/mol
• envase: pkg of 5 mg
• condiciones de almacenamiento: desiccated
• color: white
• solubilidad: DMSO: >10 mg/mL
• temp. de almacenamiento: 20-25°C
• cadena SMILES: Cl.FC(F)(F)c1ccc(CCN2CCC3(CC2)OC(=O)Nc4ccccc34)cc1
• InChI: 1S/C21H21F3N2O2.ClH/c22-21(23,24)16-7-5-15(6-8-16)9-12-26-13-10-20(11-14-26)17-3-1-2-4-18(17)25-19(27)28-20;/h1-8H,9-14H2,(H,25,27);1H
• Clave InChI: KRRISOFSWVKYBF-UHFFFAOYSA-N

Descripción

Descripción general

RS 102895 hydrochloride is a small molecule antagonist of C-C motif chemokine receptor 2 (CCR2) which belongs to the spiropiperidine (SP) class.

Aplicación

RS 102895 hydrochloride has been used in bromodeoxyuridine (5-bromo-2′-deoxyuridine, BrdU) cell proliferation assay to study effect of IL33 (interleukin 33) on decidual stromal cell proliferation in present of the antagonist and to study the effects of antagonists on the accumulation of bone marrow-derived microglia.

Acciones bioquímicas o fisiológicas

RS 102895 hydrochloride has a high affinity to the β subunit of the C-C motif chemokine receptor 2 (CCR2) and binds specifically to it. This results in the inhibition of CCR2 signaling. It also suppresses monocyte recruitment. Hence, RS 102895 may be useful for obstructing the immune suppressive effects of monocytes during early vaccine responses.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)